C S Craik
Overview
Explore the profile of C S Craik including associated specialties, affiliations and a list of published articles.
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Articles
140
Citations
3301
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Recent Articles
21.
Harris J, Craik C
Curr Opin Chem Biol
. 1998 Jul;
2(1):127-32.
PMID: 9667915
Protein engineering is the application of knowledge to design and alter protein function and structure. Although powerful methods, from specific to random, have been developed for the redesign of protein...
22.
Engineering bidentate macromolecular inhibitors for trypsin and urokinase-type plasminogen activator
Yang S, Craik C
J Mol Biol
. 1998 Jun;
279(4):1001-11.
PMID: 9642077
Ecotin, a dimeric serine protease inhibitor from Escherichia coli, is a novel platform for inhibitor design. An approach using the three-dimensional structure of the ecotin-trypsin complex to guide combinatiorial design...
23.
Yang S, Wang C, Gillmor S, Fletterick R, Craik C
J Mol Biol
. 1998 Jun;
279(4):945-57.
PMID: 9642073
The interaction between ecotin and target proteases with trypsin-like specificity has been systematically dissected to understand the structural basis of ecotin's broad inhibitory specificity and the role of the secondary...
24.
Dauber D, McPhee F, Unal A, Craik C
Adv Exp Med Biol
. 1998 Apr;
436:65-70.
PMID: 9561201
No abstract available.
25.
Craik C, Babe L, DAUBER D, McPhee F, Rose J, Unal A
Adv Exp Med Biol
. 1998 Apr;
436:31-9.
PMID: 9561196
No abstract available.
26.
Brown K, Yu Z, Burlingame A, Craik C
Biochemistry
. 1998 Apr;
37(13):4397-406.
PMID: 9521759
The Ni(II) complex of the tripeptide NH2-glycine-glycine-histidine-COOH (GGH) mediates efficient protein-protein cross-linking in the presence of oxidants such as oxone and monoperoxyphthalic acid (MMPP). Here we demonstrate that GGH fused...
27.
Rose R, Craik C, Stroud R
Biochemistry
. 1998 Mar;
37(8):2607-21.
PMID: 9485411
Rigid body rotation of five domains and movements within their interfacial joints provide a rational context for understanding why HIV protease mutations that arise in drug resistant strains are often...
28.
Caldera P, Yu Z, Knegtel R, McPhee F, Burlingame A, Craik C, et al.
Bioorg Med Chem
. 1998 Jan;
5(11):2019-27.
PMID: 9416419
Specific irreversible inhibition of the SIV protease by FMOC-protected piperidine epoxide 1 involves alkylation of the protein. Tryptic digestion of the alkylated protein and mass spectrometric analysis of the peptides...
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30.