C S Craik
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Explore the profile of C S Craik including associated specialties, affiliations and a list of published articles.
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140
Citations
3301
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Recent Articles
11.
Harris J, Backes B, Leonetti F, Mahrus S, Ellman J, Craik C
Proc Natl Acad Sci U S A
. 2000 Jun;
97(14):7754-9.
PMID: 10869434
A method is presented for the preparation and use of fluorogenic peptide substrates that allows for the configuration of general substrate libraries to rapidly identify the primary and extended specificity...
12.
Gillmor S, Takeuchi T, Yang S, Craik C, Fletterick R
J Mol Biol
. 2000 Jun;
299(4):993-1003.
PMID: 10843853
Ecotin is a dimeric serine protease inhibitor from Escherichia coli which binds proteases to form a hetero-tetramer with three distinct interfaces: an ecotin-ecotin dimer interface, a larger primary ecotin-protease interface,...
13.
Takeuchi T, Harris J, Huang W, Yan K, Coughlin S, Craik C
J Biol Chem
. 2000 Jun;
275(34):26333-42.
PMID: 10831593
Membrane-type serine protease 1 (MT-SP1) was recently cloned, and we now report its biochemical characterization. MT-SP1 is predicted to be a type II transmembrane protein with an extracellular protease domain....
14.
Todd S, Anderson C, Jolly D, Craik C
Biochim Biophys Acta
. 2000 Mar;
1477(1-2):168-88.
PMID: 10708857
The dimeric aspartyl protease of HIV has been the subject of intense research for almost a decade. Knowledge of the substrate specificity and catalytic mechanism of this enzyme initially guided...
15.
Rozzelle J, Dauber D, Todd S, Kelley R, Craik C
J Biol Chem
. 2000 Mar;
275(10):7080-6.
PMID: 10702274
Defective variants of human immunodeficiency virus type 1 (HIV-1) protease (HIV PR) have been engineered to inhibit wild-type (wt) HIV PR activity. These variants were designed to promote the formation...
16.
Backes B, Harris J, Leonetti F, Craik C, Ellman J
Nat Biotechnol
. 2000 Feb;
18(2):187-93.
PMID: 10657126
We have developed a strategy for the synthesis of positional-scanning synthetic combinatorial libraries (PS-SCL) that does not depend on the identity of the P1 substituent. To demonstrate the strategy, we...
17.
Todd S, Laboissiere M, Craik C
Anal Biochem
. 2000 Jan;
277(2):247-53.
PMID: 10625514
The yeast two-hybrid assay was used to study the dimerization of engineered and naturally occurring variants of human immunodeficiency virus (HIV) protease (PR) monomers. Defective monomers that were previously shown...
18.
Takeuchi T, Shuman M, Craik C
Proc Natl Acad Sci U S A
. 1999 Sep;
96(20):11054-61.
PMID: 10500122
Serine proteases of the chymotrypsin fold are of great interest because they provide detailed understanding of their enzymatic properties and their proposed role in a number of physiological and pathological...
19.
Pray T, Nomura A, Pennington M, Craik C
J Mol Biol
. 1999 Jun;
289(2):197-203.
PMID: 10366498
An autolysis site of functional and structural significance has been mapped within the dimer interface of Kaposi's sarcoma-associated herpesvirus protease. Cleavage 27 residues from the C terminus of the 230...
20.
Harris J, Peterson E, Hudig D, Thornberry N, Craik C
J Biol Chem
. 1998 Oct;
273(42):27364-73.
PMID: 9765264
Granzyme B is a protease involved in the induction of rapid target cell death by cytotoxic lymphocytes. Definition of the substrate specificity of granzyme B allows for the identification of...