C R Beddell
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Explore the profile of C R Beddell including associated specialties, affiliations and a list of published articles.
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Articles
46
Citations
326
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Recent Articles
1.
Kuyper L, Garvey J, Baccanari D, Champness J, Stammers D, Beddell C
Bioorg Med Chem
. 1996 Apr;
4(4):593-602.
PMID: 8735847
Conformationally restricted analogues of the antibacterial agent trimethoprim (TMP) were designed to mimic the conformation of drug observed in its complex with bacterial dihydrofolate reductase (DHFR). This conformation of TMP...
2.
Ashton D, Beddell C, Cockerill G, Gohil K, Gowrie C, Robinson J, et al.
J Chromatogr B Biomed Appl
. 1996 Feb;
677(1):194-8.
PMID: 8925096
The binding properties of six indolocarbazole derivative have been measured using immobilised human serum albumin (HSA) in an HPLC column. The compounds showed very strong binding to HSA which necessitated...
3.
Cupid B, Beddell C, Lindon J, Wilson I, Nicholson J
Xenobiotica
. 1996 Feb;
26(2):157-76.
PMID: 8868000
1. Quantitative relationships between molecular physicochemical properties of 24 substituted benzoic acids and their metabolic fate in the rabbit have been investigated using computational chemistry and multivariate statistical methods. 2....
4.
Holmes E, Sweatman B, Bollard M, Blackledge C, Beddell C, Wilson I, et al.
Xenobiotica
. 1995 Dec;
25(12):1269-81.
PMID: 8719903
1. The quantitative urinary excretion of the sulphate and glucuronide metabolites of 15 substituted phenols dosed to rat has been determined using high resolution 19F-nmr spectroscopy. 2. The urinary metabolic...
5.
Ashton D, Beddell C, Cooper D, Craig S, Lines A, Oliver R, et al.
Anal Chem
. 1995 Mar;
67(5):835-42.
PMID: 7762819
Two mass spectrometric techniques, electrospray ionization (ESI) and matrix-assisted laser desorption ionization (MALDI) have been used to study the intact humanized monoclonal antibody CAMPATH 1H, its fully and partially deglycosylated...
6.
Holmes E, Foxall P, Nicholson J, Neild G, Brown S, Beddell C, et al.
Anal Biochem
. 1994 Aug;
220(2):284-96.
PMID: 7978270
Multivariate data analysis techniques have been used to compare 600-MHz 1H nuclear magnetic resonance (NMR) spectra of urine obtained from patients with inborn errors of metabolism (IEM) and urine obtained...
7.
Anthony M, Sweatman B, Beddell C, Lindon J, Nicholson J
Mol Pharmacol
. 1994 Jul;
46(1):199-211.
PMID: 8058053
The computer-based pattern recognition procedures of nonlinear mapping and principal-component analysis have been applied to analyze 1H NMR-generated metabolic data on the biochemical effects of 15 acute nephrotoxin treatments affecting...
8.
Ashton D, Beddell C, Green B, Oliver R
FEBS Lett
. 1994 Mar;
342(1):1-6.
PMID: 8143839
A short account is presented of the method of measuring molecular masses (M(r)) of pure biological samples by electrospray ionisation mass spectrometry. It is demonstrated that the technique yields M(r)...
9.
Ashton D, Ashcroft A, Beddell C, Cooper D, Green B, Oliver R
Biochem Biophys Res Commun
. 1994 Mar;
199(2):694-8.
PMID: 8135812
In this paper the results obtained from an electrospray mass spectrometric (ES-MS) analytical study of commercial grade bovine trypsin are presented and discussed. It is proven, somewhat contrary to an...
10.
Anthony M, Gartland K, Beddell C, Lindon J, Nicholson J
Arch Toxicol
. 1994 Jan;
68(1):43-53.
PMID: 8166604
High resolution 1H NMR spectroscopy of urine and plasma, conventional clinical chemical methods and histopathology have been applied to investigate the effects of uranyl nitrate (UN) on renal function and...