B C Sweatman
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Explore the profile of B C Sweatman including associated specialties, affiliations and a list of published articles.
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23
Citations
272
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Recent Articles
1.
Salek R, Maguire M, Bentley E, Rubtsov D, Hough T, Cheeseman M, et al.
Physiol Genomics
. 2006 Dec;
29(2):99-108.
PMID: 17190852
Type 2 diabetes mellitus is the result of a combination of impaired insulin secretion with reduced insulin sensitivity of target tissues. There are an estimated 150 million affected individuals worldwide,...
2.
Ismail I, Dear G, Roberts A, Plumb R, Ayrtont J, Sweatman B, et al.
Xenobiotica
. 2002 Feb;
32(1):29-43.
PMID: 11820508
1. The urinary metabolites of the anti-convulsant compound 4-amino-1-(2,6-difluorobenzyl)-1H-1,2,3-triazolo[4,5-c]-pyridine hydrochloride (GI265080) obtained following a single oral dose to man have been detected and quantified relative to each other using 19F-NMR...
3.
Dear G, Plumb R, Sweatman B, Parry P, Roberts A, Lindon J, et al.
J Chromatogr B Biomed Sci Appl
. 2000 Nov;
748(1):295-309.
PMID: 11092606
Ion-exchange LC-MS and LC-NMR have been successfully used to identify a novel N-acetyl metabolite of a highly polar drug candidate [2-(ethanimidoylamino)ethyl]sulfonyl alanine (GW273629) under development as a therapeutic agent. This...
4.
Dear G, Plumb R, Sweatman B, Ayrton J, Lindon J, Nicholson J, et al.
J Chromatogr B Biomed Sci Appl
. 2000 Nov;
748(1):281-93.
PMID: 11092605
Mass spectrometry (both MS and MS-MS) has been used to determine which eluting chromatography peaks in an LC-MS-nuclear magnetic resonance (NMR) experiment should be selected for extended NMR spectroscopic measurement....
5.
Dear G, Ismail I, Mutch P, Plumb R, Davies L, Sweatman B
Xenobiotica
. 2000 May;
30(4):407-26.
PMID: 10821169
1. The urinary metabolites of (S)-2-ethyl-7-fluoro-3-oxo-3,4-dihydro-2H-quinoxaline-carboxylic acid isopropylester (GW420867X) have been investigated in samples obtained following oral administration to rabbit, mouse and human. GW420867X underwent extensive biotransformation to form hydroxylated...
6.
Ismail I, Dear G, Mutch P, Davies L, Plumb R, Sweatman B
Xenobiotica
. 1999 Nov;
29(9):957-67.
PMID: 10548455
1. The metabolism of (S)-2-ethyl-7-fluoro-3-oxo-3,4-dihydro-2H-quinoxalinecarboxylic acid isopropylester (GW420867X) has been investigated following oral administration to dog, cynomolgus monkey and mini-pig. 2. The urinary metabolites were isolated and characterized using semi-preparative...
7.
Dear G, Plumb R, Sweatman B, Ismail I, Ayrton J
Rapid Commun Mass Spectrom
. 1999 Jun;
13(10):886-94.
PMID: 10353224
An automated mass spectrometric linked fraction collection system is described which enables on-line examination of isolated components based on molecular-ion and product-ion information. This system has been used successfully to...
8.
Plumb R, Ayrton J, Dear G, Sweatman B, Ismail I
Rapid Commun Mass Spectrom
. 1999 Jun;
13(10):845-54.
PMID: 10353222
Preparative high performance liquid chromatography (HPLC) coupled to tandem mass spectrometry has been used successfully for the isolation of several drug metabolites from urine. Nuclear magnetic resonance (NMR) spectroscopy has...
9.
Shockcor J, Wurm R, Frick L, Sanderson P, Farrant R, Sweatman B, et al.
Xenobiotica
. 1996 Feb;
26(2):189-99.
PMID: 8868002
1. Human urine samples from a clinical trial of the anti-HIV compound (-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-cyto sin e (BW524W91) have been analysed using 19F-nmr and 1H-hplc-nmr spectroscopy. 2. The identities and relative levels...
10.
Shockcor J, Silver I, Wurm R, Sanderson P, Farrant R, Sweatman B, et al.
Xenobiotica
. 1996 Jan;
26(1):41-8.
PMID: 8851820
1. The metabolism of 1-ethylphenoxathiin-10,10-dioxide (BW1370U87), an experimental compound designed as an inhibitor of monoamine oxidase-A for use as a possible anti-depression agent, has been studied in a human liver...