C Jane McGlade
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Explore the profile of C Jane McGlade including associated specialties, affiliations and a list of published articles.
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58
Citations
2757
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Recent Articles
1.
Dho S, Othman K, Zhang Y, McGlade C
J Biol Chem
. 2025 Jan;
301(3):108215.
PMID: 39863103
The NUMB gene encodes a conserved adaptor protein with roles in asymmetric cell division and cell fate determination. First described as an inhibitor of Notch signaling, multifunctional NUMB proteins regulate...
2.
Zhang Y, Dho S, Othman K, Simpson C, Lapierre J, Bondoc A, et al.
Oncogene
. 2022 Feb;
41(14):2079-2094.
PMID: 35181737
The endocytic adaptor protein Numb acts as a tumor suppressor through downregulation of oncogenic pathways in multiple cancer types. The identification of splicing alterations giving rise to changes in Numb...
3.
Wybenga-Groot L, McGlade C
Acta Crystallogr F Struct Biol Commun
. 2021 Feb;
77(Pt 2):37-46.
PMID: 33620036
The Src-like adaptor proteins (SLAP/SLAP2) bind to CBL E3 ubiquitin ligase to downregulate antigen, cytokine and tyrosine kinase receptor signalling. In contrast to the phosphotyrosine-dependent binding of CBL substrates through...
4.
Wybenga-Groot L, Tench A, Simpson C, Germain J, Raught B, Moran M, et al.
J Mol Biol
. 2021 Feb;
433(8):166880.
PMID: 33617900
CBL is a RING type E3 ubiquitin ligase that functions as a negative regulator of tyrosine kinase signaling and loss of CBL E3 function is implicated in several forms of...
5.
Scott B, Wybenga-Groot L, McGlade C, Heon E, Peisajovich S, Chang B
SLAS Discov
. 2019 Sep;
24(10):969-977.
PMID: 31556794
Retinitis pigmentosa (RP) is a degenerative retinal disease, often caused by mutations in the G-protein-coupled receptor rhodopsin. The majority of pathogenic rhodopsin mutations cause rhodopsin to misfold, including P23H, disrupting...
6.
Dho S, Silva-Gagliardi N, Morgese F, Coyaud E, Lamoureux E, Berry D, et al.
Sci Rep
. 2019 Aug;
9(1):12471.
PMID: 31462741
MIB1 belongs to the RING domain containing family of E3 ubiquitin ligases. In vertebrates, MIB1 plays an essential role in activation of Notch signaling during development, through the ubiquitination and...
7.
Lynn B, Li X, Hormuzdi S, Griffiths E, McGlade C, Nagy J
Eur J Neurosci
. 2018 Oct;
48(9):3062-3081.
PMID: 30295974
Electrical synapses in the mammalian central nervous system (CNS) are increasingly recognized as highly complex structures for mediation of neuronal communication, both with respect to their capacity for dynamic short-...
8.
Smith T, van Slyke P, Jones N, Dumont D, McGlade C
Cell Signal
. 2018 Aug;
51:211-221.
PMID: 30077653
The inflammatory response is essential for eradication of lipopolysaccharide (LPS) presenting microbial invaders but requires exquisite regulation to prevent detrimental vascular inflammation. Endothelial cells play active roles in both the...
9.
Hirai M, Arita Y, McGlade C, Lee K, Chen J, Evans S
J Clin Invest
. 2017 Jan;
127(2):569-582.
PMID: 28067668
Failure of trabecular myocytes to undergo appropriate cell cycle withdrawal leads to ventricular noncompaction and heart failure. Signaling of growth factor receptor ERBB2 is critical for myocyte proliferation and trabeculation....
10.
Torchia J, Golbourn B, Feng S, Ho K, Sin-Chan P, Vasiljevic A, et al.
Cancer Cell
. 2016 Dec;
30(6):891-908.
PMID: 27960086
We recently reported that atypical teratoid rhabdoid tumors (ATRTs) comprise at least two transcriptional subtypes with different clinical outcomes; however, the mechanisms underlying therapeutic heterogeneity remained unclear. In this study,...