C J Walkey
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Explore the profile of C J Walkey including associated specialties, affiliations and a list of published articles.
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11
Citations
873
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Recent Articles
1.
Rosen E, Walkey C, Puigserver P, Spiegelman B
Genes Dev
. 2000 Jun;
14(11):1293-307.
PMID: 10837022
No abstract available.
2.
Agellon L, Walkey C, Vance D, Kuipers F, Verkade H
Hepatology
. 1999 Aug;
30(3):725-9.
PMID: 10462379
The liver synthesizes phosphatidylcholine (PC) de novo from choline via the CDP-choline pathway, and from phosphatidylethanolamine (PE) via the phosphatidylethanolamine N-methyltransferase (PEMT) pathway. Significant amounts of PC, which are highly...
3.
Walkey C, Shields D, Vance D
Biochim Biophys Acta
. 1999 Feb;
1436(3):405-12.
PMID: 9989271
Phosphatidylethanolamine is converted to phosphatidylcholine in mammalian liver by the enzyme phosphatidylethanolamine N-methyltransferase (PEMT). A form of the enzyme (PEMT2) has been isolated from rat liver, the cDNA cloned and...
4.
Vance D, Walkey C, Agellon L
Biochem Soc Trans
. 1998 Oct;
26(3):337-40.
PMID: 9765874
No abstract available.
5.
Walkey C, Yu L, Agellon L, Vance D
J Biol Chem
. 1998 Oct;
273(42):27043-6.
PMID: 9765216
All nucleated mammalian cells synthesize phosphatidylcholine from choline via the CDP-choline pathway. Hepatocytes have a second pathway for the synthesis of phosphatidylcholine, a stepwise methylation of phosphatidylethanolamine, catalyzed by phosphatidylethanolamine...
6.
Vance D, Walkey C
Curr Opin Lipidol
. 1998 Apr;
9(2):125-30.
PMID: 9559269
The methylation of phosphatidylethanolamine is an auxiliary pathway for phosphatidylcholine biosynthesis in liver. Two forms of the enzyme, phosphatidylethanolamine N-methyltransferase, which catalyses this reaction, are located on the endoplasmic reticulum...
7.
Walkey C, DONOHUE L, Bronson R, Agellon L, Vance D
Proc Natl Acad Sci U S A
. 1997 Dec;
94(24):12880-5.
PMID: 9371769
All nucleated cells make phosphatidylcholine via the CDP-choline pathway. Liver has an alternative pathway in which phosphatidylcholine is made by methylation of phosphatidylethanolamine catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT). We investigated...
8.
Vance D, Walkey C, Cui Z
Biochim Biophys Acta
. 1997 Nov;
1348(1-2):142-50.
PMID: 9370326
Phosphatidylethanolamine N-methyltransferase (PEMT) converts phosphatidylethanolamine to phosphatidylcholine. Most PEMT activity (PEMT1) is associated with endoplasmic reticulum. A second form of the enzyme (PEMT2) has been localized to the mitochondria-associated membrane....
9.
Walkey C, Cui Z, Agellon L, Vance D
J Lipid Res
. 1996 Nov;
37(11):2341-50.
PMID: 8978486
Phosphatidylethanolamine N-methyltransferase (PEMT) catalyzes the conversion of phosphatidylethanolamine to phosphatidylcholine in the mammalian liver via three sequential methylations. In the present studies, we cloned and characterized the murine gene for...
10.
Walkey C, Kalmar G, Cornell R
J Biol Chem
. 1994 Feb;
269(8):5742-9.
PMID: 8119913
Two rat liver cDNAs encoding CTP:phosphocholine cytidylyltransferase (CT-1 and CT-2) were expressed in COS cells. The specific activity of CT in the microsomes increased approximately 20- or 100-fold after transfection...