R B Cornell
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Explore the profile of R B Cornell including associated specialties, affiliations and a list of published articles.
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31
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578
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Recent Articles
1.
Davies S, Epand R, Kraayenhof R, Cornell R
Biochemistry
. 2001 Aug;
40(35):10522-31.
PMID: 11523994
CTP:Phosphocholine cytidylyltransferase (CT) catalyzes the key step in phosphatidylcholine (PC) synthesis. CT is activated by binding to certain lipid membranes. The membrane binding affinity of CT can vary from micromolar...
2.
Cornell R, Northwood I
Trends Biochem Sci
. 2000 Sep;
25(9):441-7.
PMID: 10973058
Phosphatidylcholine (PC) synthesis in animal cells is generally controlled by cytidine 5'-triphosphate (CTP):phosphocholine cytidylyltransferase (CCT). This enzyme is amphitropic, that is, it can interconvert between a soluble inactive form and...
3.
Drobnies A, van der Ende B, Thewalt J, Cornell R
Biochemistry
. 1999 Nov;
38(47):15606-14.
PMID: 10569945
The enzyme CTP:phosphocholine cytidylyltransferase (CT) binds reversibly to membranes and is active only in its membrane-bound form. Membrane lipid composition influences the equilibrium between its soluble and membrane-bound forms. Whereas...
4.
Johnson J, Cornell R
Mol Membr Biol
. 1999 Sep;
16(3):217-35.
PMID: 10503244
What do Src kinase, Ras-guanine nucleotide exchange factor, cytidylyltransferase, protein kinase C, phospholipase C, vinculin, and DnaA protein have in common? These proteins are amphitropic, that is, they bind weakly...
5.
Northwood I, Tong A, Crawford B, Drobnies A, Cornell R
J Biol Chem
. 1999 Sep;
274(37):26240-8.
PMID: 10473578
The transition from quiescence (G(0)) into the cell division cycle is marked by accelerated phospholipid turnover. We examined the rates of phosphatidylcholine (PC) synthesis and the activity, membrane affinity, and...
6.
Cornell R
Biochem Soc Trans
. 1998 Oct;
26(3):539-44.
PMID: 9765910
CT responds to properties of PC-depleted membranes: increased negative charge density, which concentrates the enzyme at the membrane surface, and lipid packing perturbations, which create holes in the membrane surface...
7.
Drobnies A, Venczel E, Cornell R
Biochim Biophys Acta
. 1998 Aug;
1393(1):90-8.
PMID: 9714757
CTP:phosphocholine cytidylyltransferase (CT) catalyzes a rate-limiting, regulatory step in mammalian biosynthesis of phosphocholine (PC). Anionic phospholipids, fatty acids and diacylglycerol activate CT and promote its intercalation into the lipid bilayer,...
8.
Veitch D, Gilham D, Cornell R
Eur J Biochem
. 1998 Aug;
255(1):227-34.
PMID: 9692923
The HXGH motif of CTP:phosphocholine cytidylyltransferase (CCT) is a unifying feature of the cytidylyltransferase family which has been proposed to function in binding of CTP and catalysis [Veitch, D. P....
9.
Johnson J, Rao N, Hui S, Cornell R
Biochemistry
. 1998 Jul;
37(26):9509-19.
PMID: 9649334
We are probing the mechanism of the lipid selective membrane interactions of CTP:phosphocholine cytidylyltransferase (CT). We have proposed that the membrane binding domain of CT (domain M) consists of a...
10.
Arnold R, DePaoli-Roach A, Cornell R
Biochemistry
. 1997 May;
36(20):6149-56.
PMID: 9166786
The regulation of membrane binding and activity of purified CDP:phosphocholine cytidylyl-transferase (CT) by lipid activators and enzyme dephosphorylation was examined. The binding of CT to membranes was analyzed using sucrose-loaded...