C Andrew Stewart
Overview
Explore the profile of C Andrew Stewart including associated specialties, affiliations and a list of published articles.
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21
Citations
3442
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Recent Articles
1.
Khan A, Almutairi S, Ali A, Salcedo R, Stewart C, Wang L, et al.
Front Immunol
. 2021 Jun;
12:654225.
PMID: 34093543
Natural killer (NK) cells are the predominant innate lymphocytes that provide early defense against infections. In the inflammatory milieu, NK cells modify their metabolism to support high energy demands required...
2.
Lin L, Cho S, Xing L, Wen K, Li Y, Yu T, et al.
Leukemia
. 2020 Jul;
35(3):752-763.
PMID: 32632095
Chimeric antigen receptor (CAR) T-cell therapy remains limited to select centers that can carefully monitor adverse events. To broaden use of CAR T cells in community clinics and in a...
3.
Tsoukas P, Rapp E, Van Der Kraak L, Weiss E, Dang V, Schneider C, et al.
Blood
. 2020 Jun;
136(19):2162-2174.
PMID: 32589707
Hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS) are life-threatening hyperinflammatory syndromes typically associated with underlying hematologic and rheumatic diseases, respectively. Familial HLH is associated with genetic cytotoxic impairment and...
4.
Cataisson C, Salcedo R, Michalowski A, Klosterman M, Naik S, Li L, et al.
Mol Cancer Res
. 2019 Jun;
17(8):1759-1773.
PMID: 31164412
Cancer development requires a favorable tissue microenvironment. By deleting in keratinocytes or specific bone marrow subpopulations in oncogenic RAS-mediated skin carcinogenesis, we show that IL17 from infiltrating T cells and...
5.
Ridnour L, Cheng R, Weiss J, Kaur S, Soto-Pantoja D, Basudhar D, et al.
Cancer Res
. 2015 May;
75(14):2788-99.
PMID: 25990221
Nitric oxide synthases (NOS) are important mediators of progrowth signaling in tumor cells, as they regulate angiogenesis, immune response, and immune-mediated wound healing. Ionizing radiation (IR) is also an immune...
6.
Iida N, Dzutsev A, Stewart C, Smith L, Bouladoux N, Weingarten R, et al.
Science
. 2013 Nov;
342(6161):967-70.
PMID: 24264989
The gut microbiota influences both local and systemic inflammation. Inflammation contributes to development, progression, and treatment of cancer, but it remains unclear whether commensal bacteria affect inflammation in the sterile...
7.
Stewart C, Metheny H, Iida N, Smith L, Hanson M, Steinhagen F, et al.
J Clin Invest
. 2013 Nov;
123(11):4859-74.
PMID: 24216477
The capacity of IL-10 and Tregs in the inflammatory tumor microenvironment to impair anticancer Th1 immunity makes them attractive targets for cancer immunotherapy. IL-10 and Tregs also suppress Th17 activity,...
8.
Hanson M, Hixon J, Li W, Felber B, Anver M, Stewart C, et al.
Gastroenterology
. 2013 Oct;
146(1):210-221.e13.
PMID: 24120477
Background & Aims: Treatment of inflammatory bowel disease would benefit from specific targeting of therapeutics to the intestine. We developed a strategy for localized delivery of the immunosuppressive cytokine interleukin...
9.
Grivennikov S, Wang K, Mucida D, Stewart C, Schnabl B, Jauch D, et al.
Nature
. 2012 Oct;
491(7423):254-8.
PMID: 23034650
Approximately 2% of colorectal cancer is linked to pre-existing inflammation known as colitis-associated cancer, but most develops in patients without underlying inflammatory bowel disease. Colorectal cancer often follows a genetic...
10.
Berezhnoy A, Stewart C, McNamara 2nd J, Thiel W, Giangrande P, Trinchieri G, et al.
Mol Ther
. 2012 Mar;
20(6):1242-50.
PMID: 22434135
Interleukin-10 (IL-10) is a key suppressor of inflammation in chronic infections and in cancer. In mice, the inability of the immune system to clear viral infections or inhibit tumor growth...