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Bryan K S Yeung

Explore the profile of Bryan K S Yeung including associated specialties, affiliations and a list of published articles. Areas
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Articles 24
Citations 912
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Recent Articles
1.
Moquin S, Simon O, Karuna R, Lakshminarayana S, Yokokawa F, Wang F, et al.
Sci Transl Med . 2021 Feb; 13(579). PMID: 33536278
Dengue virus (DENV) is a mosquito-borne flavivirus that poses a threat to public health, yet no antiviral drug is available. We performed a high-throughput phenotypic screen using the Novartis compound...
2.
Chua A, Ong J, Malleret B, Suwanarusk R, Kosaisavee V, Zeeman A, et al.
Nat Commun . 2019 Aug; 10(1):3635. PMID: 31406175
The ability to culture pathogenic organisms substantially enhances the quest for fundamental knowledge and the development of vaccines and drugs. Thus, the elaboration of a protocol for the in vitro...
3.
Chua A, Ananthanarayanan A, Ong J, Wong J, Yip A, Singh N, et al.
Biomaterials . 2019 Jun; 216:119221. PMID: 31195301
Hypnozoites are the liver stage non-dividing form of the malaria parasite that are responsible for relapse and acts as a natural reservoir for human malaria Plasmodium vivax and P. ovale...
4.
Kosaisavee V, Suwanarusk R, Chua A, Kyle D, Malleret B, Zhang R, et al.
Blood . 2017 Jul; 130(11):1357-1363. PMID: 28698207
Two malaria parasites of Southeast Asian macaques, and , can infect humans experimentally. In Malaysia, where both species are common, zoonotic knowlesi malaria has recently become dominant, and cases are...
5.
Kounde C, Yeo H, Wang Q, Wan K, Dong H, Karuna R, et al.
Bioorg Med Chem Lett . 2017 Feb; 27(6):1385-1389. PMID: 28216045
A series of 2-oxopiperazine derivatives were designed from the pyrrolopiperazinone cell-based screening hit 4 as a dengue virus inhibitor. Systematic investigation of the structure-activity relationship (SAR) around the piperazinone ring...
6.
Lim M, LaMonte G, Lee M, Reimer C, Tan B, Corey V, et al.
Nat Microbiol . 2016 Sep; 1:16166. PMID: 27642791
A molecular understanding of drug resistance mechanisms enables surveillance of the effectiveness of new antimicrobial therapies during development and deployment in the field. We used conventional drug resistance selection as...
7.
Zeeman A, Lakshminarayana S, van der Werff N, Klooster E, Voorberg-van der Wel A, Kondreddi R, et al.
Antimicrob Agents Chemother . 2016 Mar; 60(5):2858-63. PMID: 26926645
Two Plasmodium PI4 kinase (PI4K) inhibitors, KDU691 and LMV599, were selected for in vivo testing as causal prophylactic and radical-cure agents for Plasmodium cynomolgi sporozoite-infected rhesus macaques, based on their...
8.
Jones C, Yeung B, Manjunatha U, Shi P, Bodenreider C, Diagana T
Nat Rev Drug Discov . 2015 Jun; 14(6):442-4. PMID: 26027536
No abstract available.
9.
Lakshminarayana S, Freymond C, Fischli C, Yu J, Weber S, Goh A, et al.
Antimicrob Agents Chemother . 2014 Dec; 59(2):1200-10. PMID: 25487807
Limited information is available on the pharmacokinetic (PK) and pharmacodynamic (PD) parameters driving the efficacy of antimalarial drugs. Our objective in this study was to determine dose-response relationships of a...
10.
Zou B, Nagle A, Chatterjee A, Leong S, Tan L, Sim W, et al.
ACS Med Chem Lett . 2014 Aug; 5(8):947-50. PMID: 25147620
Imidazopyridine 1 was identified from a phenotypic screen against P. falciparum (Pf) blood stages and subsequently optimized for activity on liver-stage schizonts of the rodent parasite P. yoelii (Py) as...