Timothy A Graubert
Overview
Explore the profile of Timothy A Graubert including associated specialties, affiliations and a list of published articles.
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Articles
84
Citations
11129
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Recent Articles
1.
Zhao M, Ryall S, Brody S, Harris A, Cabral K, Brownstein C, et al.
Blood Adv
. 2025 Feb;
9(5):1003-1012.
PMID: 40014425
The detection of structural variants (SVs) represents a critical component in the diagnostic evaluation and treatment of many hematologic malignancies. Although clinical SV testing mainly consists of traditional cytogenetic methodologies,...
2.
Liu Z, Sinha S, Bannister M, Song A, Arriaga-Gomez E, McKeeken A, et al.
Cancer Res
. 2023 Nov;
84(4):577-597.
PMID: 37967363
Significance: Spliceosome-mutant leukemias accumulate R-loops and require PARP1 to resolve transcription-replication conflicts and genomic instability, providing rationale to repurpose FDA-approved PARP inhibitors for patients carrying spliceosome gene mutations.
3.
Shuman A, Aapro M, Anderson B, Arbour K, Barata P, Bardia A, et al.
Oncologist
. 2022 Aug;
PMID: 35962750
No abstract available.
4.
Wander S, Hasserjian R, Oduro K, Glomski K, Nardi V, Cote G, et al.
JCO Precis Oncol
. 2022 Feb;
1:1-7.
PMID: 35172484
A 44-year-old woman with a prior history of myxoid liposarcoma who was previously treated with radiation, chemotherapy, and resection, was admitted with syncope and pancytopenia. She was diagnosed with a...
5.
Brehmer D, Beke L, Wu T, Millar H, Moy C, Sun W, et al.
Mol Cancer Ther
. 2021 Sep;
20(12):2317-2328.
PMID: 34583982
The protein arginine methyltransferase 5 (PRMT5) methylates a variety of proteins involved in splicing, multiple signal transduction pathways, epigenetic control of gene expression, and mechanisms leading to protein expression required...
6.
Wadugu B, Nonavinkere Srivatsan S, Heard A, Alberti M, Ndonwi M, Liu J, et al.
J Clin Invest
. 2021 Sep;
131(21).
PMID: 34546980
Somatic mutations in the spliceosome gene U2AF1 are common in patients with myelodysplastic syndromes. U2AF1 mutations that code for the most common amino acid substitutions are always heterozygous, and the...
7.
Chatrikhi R, Feeney C, Pulvino M, Alachouzos G, MacRae A, Falls Z, et al.
Cell Chem Biol
. 2021 Mar;
28(8):1145-1157.e6.
PMID: 33689684
Dysregulated pre-mRNA splicing is an emerging Achilles heel of cancers and myelodysplasias. To expand the currently limited portfolio of small-molecule drug leads, we screened for chemical modulators of the U2AF...
8.
Venkataraman V, Casey K, Onozato M, Dal Cin P, Nardi V, Amrein P, et al.
Leukemia
. 2020 Jul;
34(11):3050-3054.
PMID: 32678290
No abstract available.
9.
Malcovati L, Stevenson K, Papaemmanuil E, Neuberg D, Bejar R, Boultwood J, et al.
Blood
. 2020 Apr;
136(2):157-170.
PMID: 32347921
The 2016 revision of the World Health Organization classification of tumors of hematopoietic and lymphoid tissues is characterized by a closer integration of morphology and molecular genetics. Notwithstanding, the myelodysplastic...
10.
Hasserjian R, Steensma D, Graubert T, Ebert B
Blood
. 2020 Apr;
135(20):1729-1738.
PMID: 32232484
Current objectives regarding treatment of acute myeloid leukemia (AML) include achieving complete remission (CR) by clinicopathological criteria followed by interrogation for the presence of minimal/measurable residual disease (MRD) by molecular...