Brian P McSharry
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Explore the profile of Brian P McSharry including associated specialties, affiliations and a list of published articles.
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Articles
46
Citations
2170
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Recent Articles
1.
Nematollahzadeh S, Athukorala A, Donnelly C, Pavan S, Atelie-Djossou V, Di Iorio E, et al.
Traffic
. 2024 Sep;
25(9):e12953.
PMID: 39301720
Adenoviral pVII proteins are multifunctional, highly basic, histone-like proteins that can bind to and transport the viral genome into the host cell nucleus. Despite the identification of several nuclear localization...
2.
Samer C, McWilliam H, McSharry B, Burchfield J, Stanton R, Rossjohn J, et al.
J Biol Chem
. 2024 Sep;
300(10):107748.
PMID: 39260697
Presentation of metabolites by the major histocompatibility complex class I-related protein 1 (MR1) molecule to mucosal-associated invariant T cells is impaired during herpes simplex virus type 1 (HSV-1) and type...
3.
Athukorala A, Helbig K, McSharry B, Forwood J, Sarker S
J Virol Methods
. 2024 Mar;
326:114907.
PMID: 38432358
Adenovirus protein VII (pVII) is a highly basic core protein, bearing resemblance to mammalian histones. Despite its diverse functions, a comprehensive understanding of its structural intricacies and the mechanisms underlying...
4.
Samer C, McWilliam H, McSharry B, Velusamy T, Burchfield J, Stanton R, et al.
iScience
. 2024 Feb;
27(2):108801.
PMID: 38303725
The major histocompatibility complex (MHC), Class-I-related (MR1) molecule presents microbiome-synthesized metabolites to Mucosal-associated invariant T (MAIT) cells, present at sites of herpes simplex virus (HSV) infection. During HSV type 1...
5.
Athukorala A, Donnelly C, Pavan S, Nematollahzadeh S, Djossou V, Nath B, et al.
J Gen Virol
. 2024 Jan;
105(1).
PMID: 38261399
Adenovirus protein VII (pVII) plays a crucial role in the nuclear localization of genomic DNA following viral infection and contains nuclear localization signal (NLS) sequences for the importin (IMP)-mediated nuclear...
6.
Ashley C, McSharry B, McWilliam H, Stanton R, Fielding C, Mathias R, et al.
Front Immunol
. 2023 Feb;
14:1107497.
PMID: 36845106
Introduction: The antigen presentation molecule MHC class I related protein-1 (MR1) is best characterized by its ability to present bacterially derived metabolites of vitamin B2 biosynthesis to mucosal-associated invariant T-cells...
7.
Adenoviruses in Avian Hosts: Recent Discoveries Shed New Light on Adenovirus Diversity and Evolution
Athukorala A, Helbig K, McSharry B, Forwood J, Sarker S
Viruses
. 2022 Aug;
14(8).
PMID: 36016389
While adenoviruses cause infections in a wide range of vertebrates, members of the genus , , and predominantly infect avian hosts. Several recent studies on avian adenoviruses have encouraged us...
8.
Reen F, Jump O, McEvoy G, McSharry B, Morgan J, Murphy D, et al.
FEMS Microbiol Lett
. 2022 Jun;
369(1).
PMID: 35671125
Molecular biology theory represents a critical scaffold, which underpins multiple disciplines within life sciences education. However, it is well-documented that undergraduate students can struggle to achieve deeper understanding of key...
9.
Purohit S, Samer C, McWilliam H, Traves R, Steain M, McSharry B, et al.
J Infect Dis
. 2021 Oct;
227(3):391-401.
PMID: 34648018
The antigen presentation molecule MR1 (major histocompatibility complex, class I-related) presents ligands derived from the riboflavin (vitamin B) synthesis pathway, which is not present in mammalian species or viruses, to...
10.
Steain M, Baker M, Pham C, Shanmugam N, Gambin Y, Sierecki E, et al.
PLoS Pathog
. 2020 Jul;
16(7):e1008473.
PMID: 32649716
Herpesviruses are known to encode a number of inhibitors of host cell death, including RIP Homotypic Interaction Motif (RHIM)-containing proteins. Varicella zoster virus (VZV) is a member of the alphaherpesvirus...