Brian P McSharry
Overview
Explore the profile of Brian P McSharry including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
46
Citations
2170
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
11.
McSharry B, Samer C, McWilliam H, Ashley C, Yee M, Steain M, et al.
Cell Rep
. 2020 Mar;
30(9):2948-2962.e4.
PMID: 32130899
The antigen-presenting molecule MR1 presents microbial metabolites related to vitamin B2 biosynthesis to mucosal-associated invariant T cells (MAIT cells). Although bacteria and fungi drive the MR1 biosynthesis pathway, viruses have...
12.
Gerada C, Campbell T, Kennedy J, McSharry B, Steain M, Slobedman B, et al.
Front Immunol
. 2020 Feb;
11:1.
PMID: 32038653
Varicella zoster virus (VZV) is the causative agent of chickenpox (varicella) and shingles (herpes zoster). VZV and other members of the herpesvirus family are distinguished by their ability to establish...
13.
Ashley C, Abendroth A, McSharry B, Slobedman B
Front Immunol
. 2020 Jan;
10:2751.
PMID: 31921100
The critical role of interferons (IFNs) in mediating the innate immune response to cytomegalovirus (CMV) infection is well established. However, in recent years the functional importance of the IFN-independent antiviral...
14.
Ashley C, Abendroth A, McSharry B, Slobedman B
Viruses
. 2019 Mar;
11(3).
PMID: 30871003
The antiviral activity of type I interferons (IFNs) is primarily mediated by interferon-stimulated genes (ISGs). Induction of ISG transcription is achieved when type I IFNs bind to their cognate receptor...
15.
Machala E, McSharry B, Rouse B, Abendroth A, Slobedman B
J Gen Virol
. 2019 Jan;
100(3):333-349.
PMID: 30648945
Viruses, as a class of pathogenic microbe, remain a significant health burden globally. Viral infections result in significant morbidity and mortality annually and many remain in need of novel vaccine...
16.
Machala E, Avdic S, Stern L, Zajonc D, Benedict C, Blyth E, et al.
J Virol
. 2018 Nov;
93(3).
PMID: 30487283
Human cytomegalovirus (HCMV) is a ubiquitous human herpesvirus. While HCMV infection is generally asymptomatic in the immunocompetent, it can have devastating consequences in those with compromised or underdeveloped immune systems,...
17.
Gerada C, Steain M, McSharry B, Slobedman B, Abendroth A
J Virol
. 2018 Mar;
92(12).
PMID: 29593042
There are many facets of varicella-zoster virus (VZV) pathogenesis that are not fully understood, such as the mechanisms involved in the establishment of lifelong latency, reactivation, and development of serious...
18.
Ashley C, Glass M, Abendroth A, McSharry B, Slobedman B
J Gen Virol
. 2017 Jul;
98(7):1795-1805.
PMID: 28745271
Human cytomegalovirus (HCMV) is a ubiquitous betaherpesvirus that causes life-threatening disease in immunocompromised and immunonaïve individuals. Type I interferons (IFNs) are crucial molecules in the innate immune response to HCMV...
19.
Brennan K, McSharry B, Keating S, Petrasca A, OReilly V, Keane J, et al.
Hum Immunol
. 2016 Jun;
77(10):876-885.
PMID: 27349945
NKG2D is an important activating receptor expressed on NK cells. Ligands (termed NKG2DL) for this receptor include ULBP1-6, MICA and MICB in humans; they are upregulated in stressed, cancerous or...
20.
Low H, Mukhamedova N, Cui H, McSharry B, Avdic S, Hoang A, et al.
Cell Rep
. 2016 Jun;
16(1):186-200.
PMID: 27320924
Cytomegalovirus (HCMV) contains cholesterol, but how HCMV interacts with host cholesterol metabolism is unknown. We found that, in human fibroblasts, HCMV infection increased the efflux of cellular cholesterol, despite reducing...