Richard J Stanton
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Explore the profile of Richard J Stanton including associated specialties, affiliations and a list of published articles.
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70
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Recent Articles
1.
Obergfall D, Wild M, Sommerer M, Barillas Dahm M, Kicuntod J, Tillmanns J, et al.
Pharmaceutics
. 2024 Sep;
16(9).
PMID: 39339274
. Cyclin-dependent kinase 8 (CDK8) is a multifaceted regulator and represents a catalytic component of the transcriptional Mediator complex. CDK8 activity, on the one hand, increases transcriptional elongation by the...
2.
Litvin U, Wang E, Stanton R, Fielding C, Hughes J
Virus Evol
. 2024 Sep;
10(1):veae066.
PMID: 39315401
(CMV) is a genus of herpesviruses, members of which share a long history of coevolution with their primate hosts including New World monkeys, Old World monkeys (OWMs), and Great Apes...
3.
Samer C, McWilliam H, McSharry B, Burchfield J, Stanton R, Rossjohn J, et al.
J Biol Chem
. 2024 Sep;
300(10):107748.
PMID: 39260697
Presentation of metabolites by the major histocompatibility complex class I-related protein 1 (MR1) molecule to mucosal-associated invariant T cells is impaired during herpes simplex virus type 1 (HSV-1) and type...
4.
Bliss C, Hulin-Curtis S, Williams M, Maruskova M, Davies J, Statkute E, et al.
Mol Ther Methods Clin Dev
. 2024 Aug;
32(3):101308.
PMID: 39206304
Adenoviruses (Ads) have demonstrated significant success as replication-deficient (RD) viral vectored vaccines, as well as broad potential across gene therapy and cancer therapy. Ad vectors transduce human cells via direct...
5.
Amratia P, Kerr-Jones L, Chapman L, Marsden M, Clement M, Stanton R, et al.
mBio
. 2024 Jul;
15(8):e0315223.
PMID: 38953361
Importance: Human cytomegalovirus (HCMV) causes significant disease in individuals with impaired or immature immune systems, such as transplant patients and after congenital infection. Antiviral drugs that target the virus directly...
6.
Finkel Y, Nachshon A, Aharon E, Arazi T, Simonovsky E, Dobesova M, et al.
Nature
. 2024 Jun;
630(8017):712-719.
PMID: 38839957
Genetic screens have transformed our ability to interrogate cellular factor requirements for viral infections, but most current approaches are limited in their sensitivity, biased towards early stages of infection and...
7.
Hulin-Curtis S, Geary J, MacLachlan B, Altmann D, Baillon L, Cole D, et al.
Cell Rep
. 2024 May;
43(6):114259.
PMID: 38819988
CD4 T cells are central to adaptive immunity. Their role in cross-protection in viral infections such as influenza and severe acute respiratory syndrome (SARS) is well documented; however, molecular rules...
8.
Hunter L, Kite J, Fletcher-Etherington A, Nightingale K, Nobre L, Antrobus R, et al.
J Gen Virol
. 2024 Apr;
105(4).
PMID: 38687323
The human cytomegalovirus (HCMV) pUS2 glycoprotein exploits the host's endoplasmic reticulum (ER)-associated degradation (ERAD) pathway to degrade major histocompatibility complex class I (MHC-I) and prevent antigen presentation. Beyond MHC-I, pUS2...
9.
Li H, Fletcher-Etherington A, Hunter L, Keshri S, Fielding C, Nightingale K, et al.
Cell Host Microbe
. 2024 Mar;
32(4):466-478.e11.
PMID: 38479395
Human cytomegalovirus (HCMV) is an important human pathogen that regulates host immunity and hijacks host compartments, including lysosomes, to assemble virions. We combined a quantitative proteomic analysis of HCMV infection...
10.
Samer C, McWilliam H, McSharry B, Velusamy T, Burchfield J, Stanton R, et al.
iScience
. 2024 Feb;
27(2):108801.
PMID: 38303725
The major histocompatibility complex (MHC), Class-I-related (MR1) molecule presents microbiome-synthesized metabolites to Mucosal-associated invariant T (MAIT) cells, present at sites of herpes simplex virus (HSV) infection. During HSV type 1...