Brian H Ladle
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Explore the profile of Brian H Ladle including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
500
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0
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Recent Articles
11.
Stachelek G, Ligon J, Vogel J, Levin A, Llosa N, Ladle B, et al.
Sarcoma
. 2021 May;
2021:6681741.
PMID: 33953640
Background: The majority of patients with localized Ewing sarcoma will remain disease-free long term, but for those who suffer recurrence, successful treatment remains a challenge. Identification of clinicopathologic factors predictive...
12.
Kim V, Pan X, Soares K, Azad N, Ahuja N, Gamper C, et al.
JCI Insight
. 2020 May;
5(9).
PMID: 32376802
Metastatic colorectal cancer (CRC) is poorly immunogenic, with limited neoantigens that can be targeted by cancer vaccine. Previous approaches to upregulate neoantigen have had limited success. In this study, we...
13.
Chen L, Oke T, Siegel N, Cojocaru G, Tam A, Blosser R, et al.
Clin Cancer Res
. 2020 Apr;
26(15):4018-4030.
PMID: 32332015
Purpose: Clinical trials with immune checkpoint inhibition in sarcomas have demonstrated minimal response. Here, we interrogated the tumor microenvironment (TME) of two contrasting soft-tissue sarcomas (STS), rhabdomyosarcomas and undifferentiated pleomorphic...
14.
Li K, Ladle B, Kurtulus S, Sholl A, Shanmuganad S, Hildeman D
Cell Death Differ
. 2019 Sep;
27(4):1214-1224.
PMID: 31558776
Most effector CD8 T cells die, while some persist and become either "effector" (T) or "central" (T) memory T cells. Paradoxically, effector CD8 T cells with greater memory potential have...
15.
Ladle B, Li K, Phillips M, Pucsek A, Haile A, Powell J, et al.
Proc Natl Acad Sci U S A
. 2016 Sep;
113(38):10631-6.
PMID: 27582468
DNMT3a is a de novo DNA methyltransferase expressed robustly after T-cell activation that regulates plasticity of CD4(+) T-cell cytokine expression. Here we show that DNMT3a is critical for directing early...
16.
Thomas R, Gamper C, Ladle B, Powell J, Wells A
J Biol Chem
. 2012 May;
287(27):22900-9.
PMID: 22584578
Naïve CD4+ T cells are highly plastic and can differentiate into discrete lineages with unique functions during an immune response. Once differentiated, helper T cells maintain a stable transcriptional memory...
17.
Le D, Ladle B, Lee T, Weiss V, Yao X, Leubner A, et al.
Int J Cancer
. 2010 Sep;
129(3):636-47.
PMID: 20857491
The composition of tumor infiltrating lymphocytes (TIL) is heterogeneous. In addition, the ratio of various subpopulations in the tumor microenvironment is highly dependent on the nature of the host's immune...
18.
Murata S, Ladle B, Kim P, Lutz E, Wolpoe M, Ivie S, et al.
J Immunol
. 2006 Jan;
176(2):974-83.
PMID: 16393983
T cell costimulation via OX40 is known to increase CD4+ T cell expansion and effector function and enhances the development of T cell memory. OX40 costimulation can also prevent, and...
19.
Ercolini A, Ladle B, Manning E, Pfannenstiel L, Armstrong T, Machiels J, et al.
J Exp Med
. 2005 May;
201(10):1591-602.
PMID: 15883172
A major barrier to successful antitumor vaccination is tolerance of high-avidity T cells specific to tumor antigens. In keeping with this notion, HER-2/neu (neu)-targeted vaccines, which raise strong CD8(+) T...