Brian C Grabiner
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Explore the profile of Brian C Grabiner including associated specialties, affiliations and a list of published articles.
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10
Citations
1895
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Recent Articles
1.
Picataggi A, Rodrigues A, Cromley D, Wang H, Wiener J, Garliyev V, et al.
Biochim Biophys Acta Mol Cell Biol Lipids
. 2022 Apr;
1867(7):159157.
PMID: 35381375
Adenosine triphosphate-binding cassette transporter subfamily A member 7 (ABCA7) performs incompletely understood biochemical functions that affect pathogenesis of Alzheimer's disease. ABCA7 is most similar in primary structure to ABCA1, the...
2.
Ersching J, Efeyan A, Mesin L, Jacobsen J, Pasqual G, Grabiner B, et al.
Immunity
. 2017 Jun;
46(6):1045-1058.e6.
PMID: 28636954
During antibody affinity maturation, germinal center (GC) B cells cycle between affinity-driven selection in the light zone (LZ) and proliferation and somatic hypermutation in the dark zone (DZ). Although selection...
3.
Wagle N, Grabiner B, Van Allen E, Amin-Mansour A, Taylor-Weiner A, Rosenberg M, et al.
N Engl J Med
. 2014 Oct;
371(15):1426-33.
PMID: 25295501
Everolimus, an inhibitor of the mammalian target of rapamycin (mTOR), is effective in treating tumors harboring alterations in the mTOR pathway. Mechanisms of resistance to everolimus remain undefined. Resistance developed...
4.
Grabiner B, Nardi V, Birsoy K, Possemato R, Shen K, Sinha S, et al.
Cancer Discov
. 2014 Mar;
4(5):554-63.
PMID: 24631838
Genes encoding components of the PI3K-AKT-mTOR signaling axis are frequently mutated in cancer, but few mutations have been characterized in MTOR, the gene encoding the mTOR kinase. Using publicly available...
5.
Wagle N, Grabiner B, Van Allen E, Hodis E, Jacobus S, Supko J, et al.
Cancer Discov
. 2014 Mar;
4(5):546-53.
PMID: 24625776
Understanding the genetic mechanisms of sensitivity to targeted anticancer therapies may improve patient selection, response to therapy, and rational treatment designs. One approach to increase this understanding involves detailed studies...
6.
Bar-Peled L, Chantranupong L, Cherniack A, Chen W, Ottina K, Grabiner B, et al.
Science
. 2013 Jun;
340(6136):1100-6.
PMID: 23723238
The mTOR complex 1 (mTORC1) pathway promotes cell growth in response to many cues, including amino acids, which act through the Rag guanosine triphosphatases (GTPases) to promote mTORC1 translocation to...
7.
Yang W, Wang J, Chan C, Lee S, Campos A, Lamothe B, et al.
Science
. 2009 Aug;
325(5944):1134-8.
PMID: 19713527
Akt signaling plays a central role in many biological functions, such as cell proliferation and apoptosis. Because Akt (also known as protein kinase B) resides primarily in the cytosol, it...
8.
Sun W, Li H, Yu Y, Fan Y, Grabiner B, Mao R, et al.
Cell Signal
. 2009 May;
21(10):1488-94.
PMID: 19465115
Lysophosphatidic acid (LPA) is a potent agonist that exerts various cellular functions on many cell types through binding to its cognate G protein-coupled receptors (GPCRs). Although LPA induces NF-kappaB activation...
9.
Grabiner B, Blonska M, Lin P, You Y, Wang D, Sun J, et al.
Genes Dev
. 2007 Apr;
21(8):984-96.
PMID: 17438001
G protein-coupled receptors (GPCRs) play pivotal roles in regulating various cellular functions. Although many GPCRs induce NF-kappaB activation, the molecular mechanism of GPCR-induced NF-kappaB activation remains largely unknown. CARMA3 (CARD...
10.
Kim H, Litzenburger B, Cui X, Delgado D, Grabiner B, Lin X, et al.
Mol Cell Biol
. 2007 Feb;
27(8):3165-75.
PMID: 17296734
Type I insulin-like growth factor receptor (IGF-IR) can transform mouse fibroblasts; however, little is known about the transforming potential of IGF-IR in human fibroblasts or epithelial cells. We found that...