David M Sabatini
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Explore the profile of David M Sabatini including associated specialties, affiliations and a list of published articles.
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246
Citations
76452
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Recent Articles
1.
Ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST
Sprenger H, Mittenbuhler M, Sun Y, Van Vranken J, Schindler S, Jayaraj A, et al.
Cell Metab
. 2025 Feb;
PMID: 39965563
Ergothioneine (EGT) is a diet-derived, atypical amino acid that accumulates to high levels in human tissues. Reduced EGT levels have been linked to age-related disorders, including neurodegenerative and cardiovascular diseases,...
2.
Valeros J, Jerome M, Tseyang T, Vo P, Do T, Fajardo Palomino D, et al.
Cell
. 2025 Feb;
188(4):1084-1099.e27.
PMID: 39909039
Ubiquinone (UQ), the only known electron carrier in the mammalian electron transport chain (ETC), preferentially delivers electrons to the terminal electron acceptor oxygen (O). In hypoxia, ubiquinol (UQH) diverts these...
3.
Pena I, Shi J, Chang S, Yang J, Block S, Adelmann C, et al.
Nat Commun
. 2025 Jan;
16(1):978.
PMID: 39856062
Many essential proteins require pyridoxal 5'-phosphate, the active form of vitamin B6, as a cofactor for their activity. These include enzymes important for amino acid metabolism, one-carbon metabolism, polyamine synthesis,...
4.
Valenstein M, Lalgudi P, Kedir J, Condon K, Platzek A, Freund D, et al.
Nature
. 2025 Jan;
637(8045):E11-E14.
PMID: 39780017
No abstract available.
5.
Adelmann C, Venkatachalam A, Huang L, Liu M, Germana S, Sabatini D, et al.
bioRxiv
. 2025 Jan;
PMID: 39764028
While it has been appreciated for decades that lysosomes can import cysteine, its for organismal physiology is unclear. Recently, the MFSD12 transmembrane protein was shown to be necessary to import...
6.
Chen W, Pacold M, Sabatini D, Kanarek N
Cold Spring Harb Perspect Med
. 2024 Sep;
PMID: 39284668
It is increasingly appreciated that cancer cells adapt their metabolic pathways to support rapid growth and proliferation as well as survival, often even under the poor nutrient conditions that characterize...
7.
Valenstein M, Lalgudi P, Gu X, Kedir J, Taylor M, Chivukula R, et al.
Proc Natl Acad Sci U S A
. 2024 Aug;
121(35):e2322755121.
PMID: 39163330
The mechanistic target of rapamycin complex 1 (mTORC1) pathway regulates cell growth and metabolism in response to many environmental cues, including nutrients. Amino acids signal to mTORC1 by modulating the...
8.
Sprenger H, Mittenbuhler M, Sun Y, Van Vranken J, Schindler S, Jayaraj A, et al.
bioRxiv
. 2024 Apr;
PMID: 38645260
Ergothioneine (EGT) is a diet-derived, atypical amino acid that accumulates to high levels in human tissues. Reduced EGT levels have been linked to age-related disorders, including neurodegenerative and cardiovascular diseases,...
9.
Liu G, Jouandin P, Bahng R, Perrimon N, Sabatini D
Nat Commun
. 2024 Mar;
15(1):2517.
PMID: 38514639
Animals sense and respond to nutrient availability in their environments, a task coordinated in part by the mTOR complex 1 (mTORC1) pathway. mTORC1 regulates growth in response to nutrients and,...
10.
Yu Y, Gao S, Guan Y, Hu P, Zhang Q, Liu J, et al.
Elife
. 2024 Jan;
13.
PMID: 38240316
Lysosomes are active sites to integrate cellular metabolism and signal transduction. A collection of proteins associated with the lysosome mediate these metabolic and signaling functions. Both lysosomal metabolism and lysosomal...