Brian A Stanley
Overview
Explore the profile of Brian A Stanley including associated specialties, affiliations and a list of published articles.
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14
Citations
480
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Recent Articles
1.
Tocchetti C, Stanley B, Sivakumaran V, Bedja D, ORourke B, Paolocci N, et al.
Clin Sci (Lond)
. 2015 Jul;
129(7):561-74.
PMID: 26186741
In Type I diabetic (T1DM) patients, both peaks of hyperglycaemia and increased sympathetic tone probably contribute to impair systolic and diastolic function. However, how these stressors eventually alter cardiac function...
2.
Sivakumaran V, Stanley B, Tocchetti C, Ballin J, Caceres V, Zhou L, et al.
Antioxid Redox Signal
. 2013 Aug;
19(11):1185-97.
PMID: 23919584
Aims: Nitroxyl (HNO) interacts with thiols to act as a redox-sensitive modulator of protein function. It enhances sarcoplasmic reticular Ca(2+) uptake and myofilament Ca(2+) sensitivity, improving cardiac contractility. This activity...
3.
Zgheib C, Kurdi M, Zouein F, Gunter B, Stanley B, Zgheib J, et al.
PLoS One
. 2012 Aug;
7(8):e43313.
PMID: 22905257
We previously showed that oxidative stress inhibits leukemia inhibitory factor (LIF) signaling by targeting JAK1, and the catalytic domains of JAK 1 and 2 have a cysteine-based redox switch. Thus,...
4.
Gao W, Murray C, Tian Y, Zhong X, DuMond J, Shen X, et al.
Circ Res
. 2012 Aug;
111(8):1002-11.
PMID: 22851540
Rationale: In the myocardium, redox/cysteine modification of proteins regulating Ca(2+) cycling can affect contraction and may have therapeutic value. Nitroxyl (HNO), the one-electron-reduced form of nitric oxide, enhances cardiac function...
5.
Tocchetti C, Caceres V, Stanley B, Xie C, Shi S, Watson W, et al.
Diabetes
. 2012 Jul;
61(12):3094-105.
PMID: 22807033
In type 2 diabetes, hyperglycemia and increased sympathetic drive may alter mitochondria energetic/redox properties, decreasing the organelle's functionality. These perturbations may prompt or sustain basal low-cardiac performance and limited exercise...
6.
Stanley B, Sivakumaran V, Shi S, McDonald I, Lloyd D, Watson W, et al.
J Biol Chem
. 2011 Aug;
286(38):33669-77.
PMID: 21832082
Respiring mitochondria produce H(2)O(2) continuously. When production exceeds scavenging, H(2)O(2) emission occurs, endangering cell functions. The mitochondrial peroxidase peroxiredoxin-3 reduces H(2)O(2) to water using reducing equivalents from NADPH supplied by...
7.
Stanley B, Graham D, James J, Mitsak M, Tarwater P, Robbins J, et al.
Proteomics Clin Appl
. 2011 Mar;
5(3-4):147-58.
PMID: 21365772
Purpose: Decreases in α myosin heavy chain (α-MHC) is a common feature of human heart failure (HF), whereas α-MHC overexpression in transgenic (TG) rabbits is cardioprotective against tachycardia-induced cardiomyopathy (TIC)....
8.
Tocchetti C, Stanley B, Murray C, Sivakumaran V, Donzelli S, Mancardi D, et al.
Antioxid Redox Signal
. 2011 Jan;
14(9):1687-98.
PMID: 21235349
The nitric oxide (NO(•)) sibling, nitroxyl or nitrosyl hydride (HNO), is emerging as a molecule whose pharmacological properties include providing functional support to failing hearts. HNO also preconditions myocardial tissue,...
9.
Gundry R, White M, Murray C, Kane L, Fu Q, Stanley B, et al.
Curr Protoc Mol Biol
. 2009 Oct;
Chapter 10:Unit10.25.
PMID: 19816929
This unit outlines the steps required to prepare a sample for MS analysis following protein separation or enrichment by gel electrophoresis, liquid chromatography, and affinity capture within the context of...
10.
Bovenkamp D, Stanley B, Van Eyk J
Methods Mol Biol
. 2006 Dec;
357:91-102.
PMID: 17172682
Cardiac troponin I (cTnI) is a key regulator of cardiac muscle contraction. Upon myocardial cell injury, cTnI is lost from the cardiac myocyte and can be detected in serum, in...