Brent A Hanks
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Explore the profile of Brent A Hanks including associated specialties, affiliations and a list of published articles.
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48
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1659
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Recent Articles
11.
Hanks B
Cancer Res
. 2022 Jun;
82(11):2069-2071.
PMID: 35661198
While the extracellular domain of PD-L1 is well-recognized for playing a critical role in immune evasion by suppressing CD8+ T-cell activity through direct PD-1 interactions, a series of studies has...
12.
Oswalt C, Al-Rohil R, Theivanthiran B, Haykal T, Salama A, DeVito N, et al.
J Immunother
. 2022 May;
45(6):284-290.
PMID: 35621992
The mechanisms underlying tumor immunosurveillance and their association with the immune-related adverse events (irAEs) associated with checkpoint inhibitor immunotherapies remain poorly understood. We describe a metastatic melanoma patient exhibiting multiple...
13.
Bhardwaj N, Friedlander P, Pavlick A, Ernstoff M, Gastman B, Hanks B, et al.
Nat Cancer
. 2022 Feb;
1(12):1204-1217.
PMID: 35121932
Generating responses to tumor antigens poses a challenge for immunotherapy. This phase II trial (NCT02129075) tested fms-like tyrosine kinase 3 (Flt3) ligand pre-treatment enhancement of responses to dendritic cell (DC)-targeting...
14.
DiMarco A, Qin X, McKinney B, Garcia N, Van Alsten S, Mendes E, et al.
Cancer Immunol Res
. 2021 Nov;
10(1):70-86.
PMID: 34795033
The APOBEC family of cytidine deaminases is one of the most common endogenous sources of mutations in human cancer. Genomic studies of tumors have found that APOBEC mutational signatures are...
15.
Theivanthiran B, Haykal T, Cao L, Holtzhausen A, Plebanek M, DeVito N, et al.
Cancers (Basel)
. 2021 Oct;
13(19).
PMID: 34638239
The tumor-intrinsic NOD-like receptor family, pyrin-domain-containing-3 (NLRP3) inflammasome, plays an important role in regulating immunosuppressive myeloid cell populations in the tumor microenvironment (TME). While prior studies have described the activation...
16.
Chakraborty B, Byemerwa J, Shepherd J, Haines C, Baldi R, Gong W, et al.
J Clin Invest
. 2021 Oct;
131(23).
PMID: 34637400
Immune checkpoint blockade (ICB) therapies have significantly prolonged patient survival across multiple tumor types, particularly in melanoma. Interestingly, sex-specific differences in response to ICB have been observed, with males receiving...
17.
Isaacs J, Tan A, Hanks B, Wang X, Owzar K, Herndon 2nd J, et al.
Clin Cancer Res
. 2021 Jul;
28(1):13-22.
PMID: 34312214
Clinical trials that have a pharmacokinetic or a pharmacodynamic immunologic mechanism of action-based primary outcome could substantially improve the validity and efficiency of early development of immuno-oncology agents. Here, we...
18.
DeVito N, Sturdivant M, Thievanthiran B, Xiao C, Plebanek M, Salama A, et al.
Cell Rep
. 2021 May;
35(5):109071.
PMID: 33951424
While immune checkpoint blockade is associated with prolonged responses in multiple cancers, most patients still do not benefit from this therapeutic strategy. The Wnt-β-catenin pathway is associated with diminished T ...
19.
DeVito N, Kelleher C, Strickland K, Abbruzzese J, Anders C, Hanks B, et al.
AME Case Rep
. 2021 Apr;
5:14.
PMID: 33912803
Pancreatic adenocarcinoma commonly presents as metastatic disease and harbors a dire prognosis due to its aggressive behavior, propensity for resistance to therapies, and lack of targetable driver mutations. Additionally, despite...
20.
Nghiem P, Bhatia S, Lipson E, Sharfman W, Kudchadkar R, Brohl A, et al.
J Immunother Cancer
. 2021 Apr;
9(4).
PMID: 33879601
Background: Merkel cell carcinoma (MCC) is an aggressive skin cancer associated with poor survival. Programmed cell death-1 (PD-1) pathway inhibitors have shown high rates of durable tumor regression compared with...