Michael P Plebanek
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Explore the profile of Michael P Plebanek including associated specialties, affiliations and a list of published articles.
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18
Citations
512
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Recent Articles
1.
DeVito N, Nguyen Y, Sturdivant M, Plebanek M, Villarreal K, Yarla N, et al.
Cancer Res
. 2025 Feb;
PMID: 39970333
Therapeutic resistance to immune checkpoint blockade has been commonly linked to the process of mesenchymal transformation (MT) and remains a prevalent obstacle across many cancer types. An improved mechanistic understanding...
2.
Plebanek M, Xue Y, Nguyen Y, DeVito N, Wang X, Holtzhausen A, et al.
Sci Immunol
. 2024 May;
9(95):eadi4191.
PMID: 38728412
Conventional dendritic cells (DCs) are essential mediators of antitumor immunity. As a result, cancers have developed poorly understood mechanisms to render DCs dysfunctional within the tumor microenvironment (TME). After identification...
3.
DeVito N, Nguyen Y, Sturdivant M, Plebanek M, Howell K, Yarla N, et al.
bioRxiv
. 2024 Apr;
PMID: 38617347
Significance: Gli2-induced EMT promotes immune evasion and immunotherapeutic resistance via coordinated prostaglandin and Wnt signaling.
4.
Plebanek M, Xue Y, Nguyen Y, DeVito N, Wang X, Holtzhausen A, et al.
bioRxiv
. 2023 May;
PMID: 37162965
One Sentence Summary: The metabolic transcription factor, SREBF2, regulates the development and tolerogenic function of the mregDC population within the tumor microenvironment.
5.
Theivanthiran B, Yarla N, Haykal T, Nguyen Y, Cao L, Ferreira M, et al.
Sci Transl Med
. 2022 Nov;
14(672):eabq7019.
PMID: 36417489
The tumor-intrinsic NOD-, LRR- and pyrin domain-containing protein-3 (NLRP3) inflammasome-heat shock protein 70 (HSP70) signaling axis is triggered by CD8 T cell cytotoxicity and contributes to the development of adaptive...
6.
DeVito N, Sturdivant M, Thievanthiran B, Xiao C, Plebanek M, Salama A, et al.
Cell Rep
. 2021 May;
35(5):109071.
PMID: 33951424
While immune checkpoint blockade is associated with prolonged responses in multiple cancers, most patients still do not benefit from this therapeutic strategy. The Wnt-β-catenin pathway is associated with diminished T ...
7.
Henrich S, McMahon K, Plebanek M, Calvert A, Feliciano T, Parrish S, et al.
J Extracell Vesicles
. 2021 Jan;
10(2):e12042.
PMID: 33408816
Primary tumours can establish long-range communication with distant organs to transform them into fertile soil for circulating tumour cells to implant and proliferate, a process called pre-metastatic niche (PMN) formation....
8.
Plebanek M, Sturdivant M, DeVito N, Hanks B
Int Immunol
. 2020 May;
32(7):485-491.
PMID: 32449776
The dendritic cell (DC) is recognized as a vital mediator of anti-tumor immunity. More recent studies have also demonstrated the important role of DCs in the generation of effective responses...
9.
DeVito N, Plebanek M, Theivanthiran B, Hanks B
Front Immunol
. 2020 Jan;
10:2876.
PMID: 31921140
The vast majority of cancer-related deaths are due to metastasis, a process that requires evasion of the host immune system. In addition, a significant percentage of cancer patients do not...
10.
Mirzoeva S, Tong X, Bridgeman B, Plebanek M, Volpert O
Neoplasia
. 2018 Aug;
20(9):930-942.
PMID: 30118999
We have previously demonstrated that apigenin promotes the expression of antiangiogenic protein thrombospondin-1 (TSP1) via a mechanism driven by mRNA-binding protein HuR. Here, we generated a novel mouse model with...