Alisha Holtzhausen
Overview
Explore the profile of Alisha Holtzhausen including associated specialties, affiliations and a list of published articles.
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Citations
891
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Recent Articles
1.
Prieto-Dominguez N, Goel P, Ojo O, Moretto K, Holtzhausen A, Humphryes A, et al.
Cancer Immunol Res
. 2025 Feb;
PMID: 39937118
Traditional anti-cancer therapies induce tumor cell death and subsequent release of Damage Associated Molecular Patterns (DAMPs) that activate the innate inflammatory response. Paradoxically, after treatment, macrophages often adopt a pro-wound...
2.
Tanim K, Holtzhausen A, Thapa A, Huelse J, Graham D, Earp H
Int J Mol Sci
. 2024 Jul;
25(14).
PMID: 39062902
In this issue honoring the contributions of Greg Lemke, the Earp and Graham lab teams discuss several threads in the discovery, action, signaling, and translational/clinical potential of MERTK, originally called...
3.
Zewdie E, Edwards G, Hunter D, Earp H, Holtzhausen A
Cancer Immunol Res
. 2024 Jul;
12(9):1268-1285.
PMID: 38976507
Checkpoint inhibitors, specifically anti-programmed cell death protein 1 (PD1), have shown success in treating metastatic melanoma; however, some patients develop resistance. Dendritic cells (DC) play a key role in initiating...
4.
Plebanek M, Xue Y, Nguyen Y, DeVito N, Wang X, Holtzhausen A, et al.
Sci Immunol
. 2024 May;
9(95):eadi4191.
PMID: 38728412
Conventional dendritic cells (DCs) are essential mediators of antitumor immunity. As a result, cancers have developed poorly understood mechanisms to render DCs dysfunctional within the tumor microenvironment (TME). After identification...
5.
Plebanek M, Xue Y, Nguyen Y, DeVito N, Wang X, Holtzhausen A, et al.
bioRxiv
. 2023 May;
PMID: 37162965
One Sentence Summary: The metabolic transcription factor, SREBF2, regulates the development and tolerogenic function of the mregDC population within the tumor microenvironment.
6.
Theivanthiran B, Yarla N, Haykal T, Nguyen Y, Cao L, Ferreira M, et al.
Sci Transl Med
. 2022 Nov;
14(672):eabq7019.
PMID: 36417489
The tumor-intrinsic NOD-, LRR- and pyrin domain-containing protein-3 (NLRP3) inflammasome-heat shock protein 70 (HSP70) signaling axis is triggered by CD8 T cell cytotoxicity and contributes to the development of adaptive...
7.
Oswalt C, Al-Rohil R, Theivanthiran B, Haykal T, Salama A, DeVito N, et al.
J Immunother
. 2022 May;
45(6):284-290.
PMID: 35621992
The mechanisms underlying tumor immunosurveillance and their association with the immune-related adverse events (irAEs) associated with checkpoint inhibitor immunotherapies remain poorly understood. We describe a metastatic melanoma patient exhibiting multiple...
8.
Theivanthiran B, Haykal T, Cao L, Holtzhausen A, Plebanek M, DeVito N, et al.
Cancers (Basel)
. 2021 Oct;
13(19).
PMID: 34638239
The tumor-intrinsic NOD-like receptor family, pyrin-domain-containing-3 (NLRP3) inflammasome, plays an important role in regulating immunosuppressive myeloid cell populations in the tumor microenvironment (TME). While prior studies have described the activation...
9.
DeVito N, Sturdivant M, Thievanthiran B, Xiao C, Plebanek M, Salama A, et al.
Cell Rep
. 2021 May;
35(5):109071.
PMID: 33951424
While immune checkpoint blockade is associated with prolonged responses in multiple cancers, most patients still do not benefit from this therapeutic strategy. The Wnt-β-catenin pathway is associated with diminished T ...
10.
Theivanthiran B, Evans K, DeVito N, Plebanek M, Sturdivant M, Wachsmuth L, et al.
J Clin Invest
. 2020 Feb;
130(5):2570-2586.
PMID: 32017708
An in-depth understanding of immune escape mechanisms in cancer is likely to lead to innovative advances in immunotherapeutic strategies. However, much remains unknown regarding these mechanisms and how they impact...