Bradley W McIntyre
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Explore the profile of Bradley W McIntyre including associated specialties, affiliations and a list of published articles.
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30
Citations
954
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Recent Articles
1.
Brown W, Khalili J, Rodriguez-Cruz T, Lizee G, McIntyre B
J Biol Chem
. 2014 Jun;
289(33):23141-23153.
PMID: 24936068
The regulation of integrin-mediated adhesion is of vital importance to adaptive and innate immunity. Integrins are versatile proteins and mediate T cell migration and trafficking by binding to extracellular matrix...
2.
Fiorcari S, Brown W, McIntyre B, Estrov Z, Maffei R, OBrien S, et al.
PLoS One
. 2013 Dec;
8(12):e83830.
PMID: 24376763
CLL cell trafficking between blood and tissue compartments is an integral part of the disease process. Idelalisib, a phosphoinositide 3-kinase delta (PI3Kδ) inhibitor causes rapid lymph node shrinkage, along with...
3.
CD25 and CD69 induction by α4β1 outside-in signalling requires TCR early signalling complex proteins
Cimo A, Ahmed Z, McIntyre B, Lewis D, Ladbury J
Biochem J
. 2013 Jun;
454(1):109-21.
PMID: 23758320
Distinct signalling pathways producing diverse cellular outcomes can utilize similar subsets of proteins. For example, proteins from the TCR (T-cell receptor) ESC (early signalling complex) are also involved in interferon-α...
4.
Vanderslice P, Biediger R, Woodside D, Brown W, Khounlo S, Warier N, et al.
J Biol Chem
. 2013 May;
288(27):19414-28.
PMID: 23703610
Activation of the integrin family of cell adhesion receptors on progenitor cells may be a viable approach to enhance the effects of stem cell-based therapies by improving cell retention and...
5.
Lee Y, Jin J, Cheng C, Huang C, Song J, Huang M, et al.
Mol Cancer Res
. 2013 Jan;
11(4):405-17.
PMID: 23339185
Disseminated prostate cancer cells must survive in circulation for metastasis to occur. Mechanisms by which these cells survive are not well understood. By immunohistochemistry of human tissues, we found that...
6.
Gundlach 4th C, Caivano A, Cabreira-Hansen M, Gahremanpour A, Brown W, Zheng Y, et al.
Bioconjug Chem
. 2011 Jul;
22(8):1706-14.
PMID: 21749133
A key issue regarding the use of stem cells in cardiovascular regenerative medicine is their retention in target tissues. Here, we have generated and assessed a bispecific antibody heterodimer designed...
7.
Sergeeva A, Alatrash G, He H, Ruisaard K, Lu S, Wygant J, et al.
Blood
. 2011 Feb;
117(16):4262-72.
PMID: 21296998
PR1 (VLQELNVTV) is a human leukocyte antigen-A2 (HLA-A2)-restricted leukemia-associated peptide from proteinase 3 (P3) and neutrophil elastase (NE) that is recognized by PR1-specific cytotoxic T lymphocytes that contribute to cytogenetic...
8.
Vanderslice P, Woodside D, Caivano A, Decker E, Munsch C, Sherwood S, et al.
Biochem Biophys Res Commun
. 2010 Sep;
400(4):619-24.
PMID: 20807504
The development of antagonists to the α4 integrin family of cell adhesion molecules has been an active area of pharmaceutical research to treat inflammatory and autoimmune diseases. Presently being tested...
9.
Carreno R, Brown W, Li D, Hernandez J, Wang Y, Kim T, et al.
J Biol Chem
. 2010 Aug;
285(43):32860-32868.
PMID: 20724473
The activation of leukocyte function-associated antigen-1 (LFA-1) plays a critical role in regulating immune responses. The metal ion-dependent adhesion site on the I-domain of LFA-1 α(L) subunit is the key...
10.
Sood A, Armaiz-Pena G, Halder J, Nick A, Stone R, Hu W, et al.
J Clin Invest
. 2010 Apr;
120(5):1515-23.
PMID: 20389021
Chronic stress is associated with hormonal changes that are known to affect multiple systems, including the immune and endocrine systems, but the effects of stress on cancer growth and progression...