Bradley E Britigan
Overview
Explore the profile of Bradley E Britigan including associated specialties, affiliations and a list of published articles.
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70
Citations
1890
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Recent Articles
1.
Choi S, Kulkarni S, Arnett E, Schlesinger L, Britigan B, Narayanasamy P
ACS Infect Dis
. 2024 Nov;
10(12):4279-4290.
PMID: 39499869
Coinfection of (Mtb) and human immunodeficiency virus-1 (HIV) is a significant public health concern. Treatment is challenging due to prolonged duration of therapy and drug interactions between antiretroviral therapy (ART)...
2.
Choi S, Hassan M, Britigan B, Narayanasamy P
Curr Issues Mol Biol
. 2024 Aug;
46(8):9149-9161.
PMID: 39194758
Metals play vital roles in biological systems, with iron/heme being essential for cellular and metabolic functions necessary for survival and/or virulence in many bacterial pathogens. Given the rise of bacterial...
3.
Choi S, Talmon G, Hearne K, Woo J, Truong V, Britigan B, et al.
Mol Pharm
. 2023 Jul;
20(8):4058-4070.
PMID: 37471668
There is a major need for the development of new therapeutics to combat antibiotic-resistant . Recently, gallium (Ga)-based complexes have shown promising antimicrobial effects against various bacteria, including multidrug-resistant organisms,...
4.
Scott Z, Choi S, Britigan B, Narayanasamy P
ACS Infect Dis
. 2023 Mar;
9(4):716-738.
PMID: 36995299
The treatment of infections is becoming more difficult due to emerging resistance of pathogens to existing drugs. As such, alternative druggable targets, particularly those that are essential for microbe viability...
5.
Scott Z, Choi S, Talmon G, Britigan B, Narayanasamy P
ACS Infect Dis
. 2022 Sep;
8(10):2096-2105.
PMID: 36049087
is a highly antibiotic-resistant opportunistic pathogenic bacteria that is responsible for thousands of deaths each year. Infections with disproportionately impact individuals with compromised immune systems as well as cystic fibrosis...
6.
Choi S, Britigan B, Narayanasamy P
Bioorg Med Chem Lett
. 2022 Feb;
62:128645.
PMID: 35219822
Bacterial heme uptake pathways offer a novel target for antimicrobial drug discovery. Recently, gallium (Ga) porphyrin complexes were found to be effective against mycobacterial heme uptake pathways. The goal of...
7.
Narayanasamy P, Switzer B, Britigan B
Sci Rep
. 2021 Sep;
11(1):17757.
PMID: 34471220
No abstract available.
8.
Choi S, Talmon G, Britigan B, Narayanasamy P
ACS Infect Dis
. 2021 Jul;
7(8):2299-2309.
PMID: 34314150
The emergence of drug-resistant pathogens causes the greatest challenge for drug development research. Recently, gallium(III)-based compounds have received great attention as novel antimicrobial agents against drug-resistant pathogens. Here, we synthesized...
9.
Ahmad I, Dafferner A, OConnell K, Mehla K, Britigan B, Hollingsworth M, et al.
Cancers (Basel)
. 2021 Jun;
13(9).
PMID: 34066839
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a poor prognosis. Tumor hypoxia plays an active role in promoting tumor progression, malignancy, and resistance to therapy in PDAC. We...
10.
Choi S, Switzer B, Britigan B, Narayanasamy P
ACS Infect Dis
. 2020 Aug;
6(10):2582-2591.
PMID: 32845117
There is an urgent need for new effective and safe antibiotics active against pathogenic mycobacterial species. Gallium (Ga) nitrate (Ga(NO)) and Ga porphyrin (GaPP) have each been shown to inhibit...