Prabagaran Narayanasamy
Overview
Explore the profile of Prabagaran Narayanasamy including associated specialties, affiliations and a list of published articles.
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Articles
46
Citations
783
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Recent Articles
1.
Frandsen J, Yuan Z, Bedi B, Prasla Z, Choi S, Narayanasamy P, et al.
PLoS One
. 2025 Feb;
20(2):e0310908.
PMID: 39913377
Nontuberculous Mycobacteria (NTM) are a heterogeneous group of environmental microorganisms with distinct human pathogenesis. Their incidence and prevalence are rising worldwide, due in part to elevated antimicrobial resistance which complicates...
2.
Choi S, Kulkarni S, Arnett E, Schlesinger L, Britigan B, Narayanasamy P
ACS Infect Dis
. 2024 Nov;
10(12):4279-4290.
PMID: 39499869
Coinfection of (Mtb) and human immunodeficiency virus-1 (HIV) is a significant public health concern. Treatment is challenging due to prolonged duration of therapy and drug interactions between antiretroviral therapy (ART)...
3.
Choi S, Hassan M, Britigan B, Narayanasamy P
Curr Issues Mol Biol
. 2024 Aug;
46(8):9149-9161.
PMID: 39194758
Metals play vital roles in biological systems, with iron/heme being essential for cellular and metabolic functions necessary for survival and/or virulence in many bacterial pathogens. Given the rise of bacterial...
4.
Choi S, Narayanasamy P
Microorganisms
. 2024 Jan;
12(1).
PMID: 38276186
In a recent effort to mitigate harm from human pathogens, many biosynthetic pathways have been extensively evaluated for their ability to inhibit pathogen growth and to determine drug targets. One...
5.
Choi S, Narayanasamy P
ACS Infect Dis
. 2023 Sep;
9(10):2016-2024.
PMID: 37655755
Menaquinone (MK) is an essential component in the oxidative phosphorylation pathway of Gram-positive bacteria. Drugs targeting enzymes involved in MK biosynthesis can prevent electron transfer, which leads to ATP starvation...
6.
Choi S, Talmon G, Hearne K, Woo J, Truong V, Britigan B, et al.
Mol Pharm
. 2023 Jul;
20(8):4058-4070.
PMID: 37471668
There is a major need for the development of new therapeutics to combat antibiotic-resistant . Recently, gallium (Ga)-based complexes have shown promising antimicrobial effects against various bacteria, including multidrug-resistant organisms,...
7.
Scott Z, Choi S, Britigan B, Narayanasamy P
ACS Infect Dis
. 2023 Mar;
9(4):716-738.
PMID: 36995299
The treatment of infections is becoming more difficult due to emerging resistance of pathogens to existing drugs. As such, alternative druggable targets, particularly those that are essential for microbe viability...
8.
Scott Z, Choi S, Talmon G, Britigan B, Narayanasamy P
ACS Infect Dis
. 2022 Sep;
8(10):2096-2105.
PMID: 36049087
is a highly antibiotic-resistant opportunistic pathogenic bacteria that is responsible for thousands of deaths each year. Infections with disproportionately impact individuals with compromised immune systems as well as cystic fibrosis...
9.
Frandsen J, Narayanasamy P
ACS Chem Neurosci
. 2022 Apr;
13(8):1165-1177.
PMID: 35385645
Cannabidiol is a nonpsychoactive phytocannabinoid produced by the plant and possesses a wide range of pharmacological activities, including anti-inflammatory, antioxidant, and neuroprotective activities. Cannabidiol functions in a neuroprotective manner, in...
10.
Choi S, Britigan B, Narayanasamy P
Bioorg Med Chem Lett
. 2022 Feb;
62:128645.
PMID: 35219822
Bacterial heme uptake pathways offer a novel target for antimicrobial drug discovery. Recently, gallium (Ga) porphyrin complexes were found to be effective against mycobacterial heme uptake pathways. The goal of...