Brad Dykstra
Overview
Explore the profile of Brad Dykstra including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
1265
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0
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Recent Articles
1.
Mondal N, Dykstra B, Lee J, Ashline D, Reinhold V, Rossi D, et al.
J Biol Chem
. 2018 Mar;
293(19):7300-7314.
PMID: 29593094
In humans, six α(1,3)-fucosyltransferases (α(1,3)-FTs: FT3/FT4/FT5/FT6/FT7/FT9) reportedly fucosylate terminal lactosaminyl glycans yielding Lewis-X (Le; CD15) and/or sialyl Lewis-X (sLe; CD15s), structures that play key functions in cell migration, development, and...
2.
Donnelly C, Dykstra B, Mondal N, Huang J, Kaskow B, Griffin R, et al.
Sci Rep
. 2018 Jan;
8(1):420.
PMID: 29323143
While human Tregs hold immense promise for immunotherapy, their biologic variability poses challenges for clinical use. Here, we examined clinically-relevant activities of defined subsets of freshly-isolated and culture-expanded human PBMC-derived...
3.
Lee J, Dykstra B, Spencer J, Kenney L, Greiner D, Shultz L, et al.
J Clin Invest
. 2017 May;
127(6):2433-2437.
PMID: 28481220
Generation of functional hematopoietic stem and progenitor cells (HSPCs) from human pluripotent stem cells (PSCs) has been a long-sought-after goal for use in hematopoietic cell production, disease modeling, and eventually...
4.
Dykstra B, Lee J, Mortensen L, Yu H, Wu Z, Lin C, et al.
Stem Cells
. 2016 Jun;
34(10):2501-2511.
PMID: 27335219
Human mesenchymal stem cells (MSCs) hold great promise in cellular therapeutics for skeletal diseases but lack expression of E-selectin ligands that direct homing of blood-borne cells to bone marrow. Previously,...
5.
Lee J, Dykstra B, Sackstein R, Rossi D
Curr Opin Hematol
. 2015 Jun;
22(4):317-23.
PMID: 26049752
Purpose Of Review: Human pluripotent stem cells (PSCs) have the potential to provide an inexhaustible source of hematopoietic stem cells (HSCs) that could be used in disease modeling and in...
6.
Dykstra B, Bystrykh L
Cell Stem Cell
. 2014 Apr;
14(4):419-20.
PMID: 24702990
Clonal tracking of hematopoietic stem and progenitor cells (HSPCs) has proven valuable for studying their behavior in murine recipients. Now in Cell Stem Cell, Kim et al. (2014) and Wu...
7.
Dykstra B, Olthof S, Schreuder J, Ritsema M, de Haan G
J Exp Med
. 2011 Nov;
208(13):2691-703.
PMID: 22110168
Hematopoietic stem cell (HSC) populations change with aging, but the extent to which this is caused by qualitative versus quantitative alterations in HSC subtypes is unclear. Using clonal assays, in...
8.
Gerrits A, Dykstra B, Kalmykowa O, Klauke K, Verovskaya E, Broekhuis M, et al.
Blood
. 2010 Jan;
115(13):2610-8.
PMID: 20093403
Clonal analysis is important for many areas of hematopoietic stem cell research, including in vitro cell expansion, gene therapy, and cancer progression and treatment. A common approach to measure clonality...
9.
Kent D, Dykstra B, Eaves C
Curr Protoc Stem Cell Biol
. 2008 Sep;
Chapter 2:Unit 2A.4.
PMID: 18785176
Suspensions of multipotent hematopoietic stem cells with long-term repopulating activity can now be routinely isolated from adult mouse bone marrow at purities of 30%. A robust method for obtaining these...
10.
Gerrits A, Dykstra B, Otten M, Bystrykh L, de Haan G
Immunogenetics
. 2008 Jun;
60(8):411-22.
PMID: 18560825
Stem cells are unique in that they possess both the capacity to self-renew and thereby maintain their original pool as well as the capacity to differentiate into mature cells. In...