Brad Dykstra
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Explore the profile of Brad Dykstra including associated specialties, affiliations and a list of published articles.
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19
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1265
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Recent Articles
11.
Miller C, Dykstra B, Eaves C
Curr Protoc Immunol
. 2008 Apr;
Chapter 22:22B.2.1-22B.2.31.
PMID: 18432636
The unit describes functional assays for the quantification of mouse hematopoietic stem cells and progenitor cells. The competitive repopulating unit (CRU) assay detects transplantable mouse hematopoietic stem cells with the...
12.
Kent D, Copley M, Benz C, Dykstra B, Bowie M, Eaves C
Clin Cancer Res
. 2008 Apr;
14(7):1926-30.
PMID: 18381929
Understanding the intrinsic pathways that regulate hematopoietic stem cell (HSC) proliferation and self-renewal responses to external signals offers a rational approach to developing improved strategies for HSC expansion for therapeutic...
13.
Dykstra B, Kent D, Bowie M, McCaffrey L, Hamilton M, Lyons K, et al.
Cell Stem Cell
. 2008 Mar;
1(2):218-29.
PMID: 18371352
Heterogeneity in the differentiation behavior of hematopoietic stem cells is well documented but poorly understood. To investigate this question at a clonal level, we isolated a subpopulation of adult mouse...
14.
Dykstra B, de Haan G
Cell Tissue Res
. 2007 Nov;
331(1):91-101.
PMID: 18008087
A functional decline of the immune system occurs during organismal aging that is attributable, in large part, to changes in the hematopoietic stem cell (HSC) compartment. In the mouse, several...
15.
Bowie M, Kent D, Dykstra B, McKnight K, McCaffrey L, Hoodless P, et al.
Proc Natl Acad Sci U S A
. 2007 Mar;
104(14):5878-82.
PMID: 17379664
Hematopoietic stem cells (HSCs) execute self-renewal divisions throughout fetal and adult life, although some of their properties do alter. Here we analyzed the magnitude and timing of changes in the...
16.
Dykstra B, Ramunas J, Kent D, McCaffrey L, Szumsky E, Kelly L, et al.
Proc Natl Acad Sci U S A
. 2006 May;
103(21):8185-90.
PMID: 16702542
To search for new indicators of self-renewing hematopoietic stem cells (HSCs), highly purified populations were isolated from adult mouse marrow, micromanipulated into a specially designed microscopic array, and cultured for...
17.
Sieburg H, Cho R, Dykstra B, Uchida N, Eaves C, Muller-Sieburg C
Blood
. 2005 Nov;
107(6):2311-6.
PMID: 16291588
Hematopoietic stem cells (HSCs) display extensive heterogeneity in their behavior even when isolated as phenotypically homogeneous populations. It is not clear whether this heterogeneity reflects inherently diverse subsets of HSCs...
18.
Uchida N, Dykstra B, Lyons K, Leung F, Kristiansen M, Eaves C
Blood
. 2004 Feb;
103(12):4487-95.
PMID: 14988157
Primitive hematopoietic cells from several species are known to efflux both Hoechst 33342 and Rhodamine-123. We now show that murine hematopoietic stem cells (HSCs) defined by long-term multilineage repopulation assays...
19.
Uchida N, Dykstra B, Lyons K, Leung F, Eaves C
Exp Hematol
. 2003 Dec;
31(12):1338-47.
PMID: 14662343
Objective: The Hoechst 33342-effluxing side population (SP) of adult mouse bone marrow (BM) contains most of the hematopoietic stem cells (HSCs). Here we measured the HSC content of specific subsets...