Bobby L Barnett
Overview
Explore the profile of Bobby L Barnett including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
6
Citations
348
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Tsoumpra M, Muniz J, Barnett B, Kwaasi A, Pilka E, Kavanagh K, et al.
Bone
. 2015 Aug;
81:478-486.
PMID: 26318908
Farnesyl pyrophosphate synthase (FPPS) is the major molecular target of nitrogen-containing bisphosphonates (N-BPs), used clinically as bone resorption inhibitors. We investigated the role of threonine 201 (Thr201) and tyrosine 204...
2.
Ebetino F, Hogan A, Sun S, Tsoumpra M, Duan X, Triffitt J, et al.
Bone
. 2011 Apr;
49(1):20-33.
PMID: 21497677
The ability of bisphosphonates ((HO)(2)P(O)CR(1)R(2)P(O)(OH)(2)) to inhibit bone resorption has been known since the 1960s, but it is only recently that a detailed molecular understanding of the relationship between chemical...
3.
Deprele S, Kashemirov B, Hogan J, Ebetino F, Barnett B, Evdokimov A, et al.
Bioorg Med Chem Lett
. 2008 Apr;
18(9):2878-82.
PMID: 18434151
The complex formed from crystallization of human farnesyl pyrophosphate synthase (hFPPS) from a solution of racemic [6,7-dihydro-5H-cyclopenta[c]pyridin-7-yl(hydroxy)methylene]bis(phosphonic acid) (NE-10501, 8), a chiral analog of the anti-osteoporotic drug risedronate, contained the...
4.
Dunford J, Kwaasi A, Rogers M, Barnett B, Ebetino F, Russell R, et al.
J Med Chem
. 2008 Mar;
51(7):2187-95.
PMID: 18327899
The nitrogen-containing bisphosphonates (N-BPs) are the main drugs currently used to treat diseases characterized by excessive bone resorption. The major molecular target of N-BPs is farnesylpyrophosphate synthase. N-BPs inhibit the...
5.
Russell R, Xia Z, Dunford J, Oppermann U, Kwaasi A, Hulley P, et al.
Ann N Y Acad Sci
. 2007 Dec;
1117:209-57.
PMID: 18056045
The bisphosphonates (BPs) are well established as the treatments of choice for disorders of excessive bone resorption, including Paget's disease of bone, myeloma and bone metastases, and osteoporosis. There is...
6.
Evdokimov A, Pokross M, Walter R, Mekel M, Barnett B, Amburgey J, et al.
Proteins
. 2006 Nov;
66(3):538-46.
PMID: 17120228
In this article we describe the application of structural biology methods to the discovery of novel potent inhibitors of methionine aminopeptidases. These enzymes are employed by the cells to cleave...