Bikash Debnath
Overview
Explore the profile of Bikash Debnath including associated specialties, affiliations and a list of published articles.
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39
Citations
923
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Recent Articles
11.
Zhang F, Debnath B, Xu Z, Yang L, Song L, Zheng Y, et al.
Eur J Med Chem
. 2016 Nov;
125:1051-1063.
PMID: 27810592
Currently, three HIV-1 integrase (IN) active site-directed inhibitors are in clinical use for the treatment of HIV infection. However, emergence of drug resistance mutations have limited the promise of a...
12.
Ramkumar K, Samanta S, Kyani A, Yang S, Tamura S, Ziemke E, et al.
Nat Commun
. 2016 Oct;
7:13084.
PMID: 27703239
Glutathione S-transferase omega 1 (GSTO1) is an atypical GST isoform that is overexpressed in several cancers and has been implicated in drug resistance. Currently, no small-molecule drug targeting GSTO1 is...
13.
Ha H, Debnath B, Odde S, Bensman T, Ho H, Beringer P, et al.
J Chem Inf Model
. 2015 Jul;
55(8):1720-38.
PMID: 26153616
The chemokine receptor CXCR2 is expressed on various immune cells and is essential for neutrophil recruitment and angiogenesis at sites of acute and chronic inflammation caused by tissue injury or...
14.
Zhang D, Debnath B, Yu S, Sanchez T, Christ F, Liu Y, et al.
Bioorg Med Chem
. 2014 Aug;
22(19):5446-53.
PMID: 25150089
Raltegravir (RAL) is a first clinically approved integrase (IN) inhibitor for the treatment of HIV but rapid mutation of the virus has led to chemo-resistant strains. Therefore, there is a...
15.
Serrao E, Xu Z, Debnath B, Christ F, Debyser Z, Long Y, et al.
Bioorg Med Chem
. 2013 Aug;
21(19):5963-72.
PMID: 23985689
Though much progress has been made in the inhibition of HIV-1 integrase catalysis, clinical resistance mutations have limited the promise of long-term drug prescription. Consequently, allosteric inhibition of integrase activity...
16.
Xu S, Oshima T, Imada T, Masuda M, Debnath B, Grande F, et al.
Cancer Lett
. 2013 Mar;
335(2):421-30.
PMID: 23481022
Colon cancer is one of the most commonly diagnosed cancers in the United States. Recombinant MDA-7/IL-24 has showed its selective cytotoxicity against cancer cells, and Ad-mda7 (INGN-241) is currently under...
17.
Serrao E, Debnath B, Otake H, Kuang Y, Christ F, Debyser Z, et al.
J Med Chem
. 2013 Mar;
56(6):2311-22.
PMID: 23445471
On the basis of an initial molecular modeling study suggesting the favorable binding of the "privileged" fragment 8-hydroxyquinoline with HIV-1 integrase (IN) at the IN-lens epithelium-derived growth factor/p75 (LEDGF/p75) interface...
18.
Debnath B, Xu S, Grande F, Garofalo A, Neamati N
Theranostics
. 2013 Feb;
3(1):47-75.
PMID: 23382786
CXCR4 is a G-protein-coupled receptor involved in a number of physiological processes in the hematopoietic and immune systems. The SDF-1/CXCR4 axis is significantly associated with several diseases, such as HIV,...
19.
Sanchez T, Debnath B, Christ F, Otake H, Debyser Z, Neamati N
Bioorg Med Chem
. 2013 Jan;
21(4):957-63.
PMID: 23306052
Human lens epithelium-derived growth factor (LEDGF)/p75 plays an important role in the HIV life cycle by stimulating integrase (IN)-led viral DNA integration into cellular chromosomes. Mechanistic studies show the majority...
20.
Zeng L, Wang Y, Kazemi R, Xu S, Xu Z, Sanchez T, et al.
J Med Chem
. 2012 Oct;
55(22):9492-509.
PMID: 23098137
Among a large number of HIV-1 integrase (IN) inhibitors, the 8-hydroxy-[1,6]naphthyridines (i.e., L-870,810) were one of the promising class of antiretroviral drugs developed by Merck Laboratories. In spite of its...