Bikash Debnath
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Explore the profile of Bikash Debnath including associated specialties, affiliations and a list of published articles.
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39
Citations
923
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Recent Articles
1.
Choudhury P, Ikbal A, Saha S, Debnath R, Debnath B, Singh L, et al.
Curr Top Med Chem
. 2024 Oct;
PMID: 39473113
Rapid growth in nanotechnology, also known as 21st-century technology, is occurring in response to the increasing diversity of diseases. The development of safe and effective drug delivery methods to enhance...
2.
Kassa S, Das J, Lamba V, De D, Debnath B, Mallik S, et al.
Sci Rep
. 2024 May;
14(1):10532.
PMID: 38720092
The article introduces a revolutionary Nanorouter structure, which is a crucial component in the Nano communication regime. To complete the connection, many key properties of Nanorouters are investigated and merged....
3.
Yao J, Yin Y, Han H, Chen S, Zheng Y, Liang B, et al.
Eur J Med Chem
. 2022 Dec;
247:115024.
PMID: 36543033
Sirtiun 5 (SIRT5) is a NAD-dependent protein lysine deacylase. It is emerging as a promising target for the development of drugs to treat cancer and metabolism-related diseases. In this study,...
4.
Liu Y, Debnath B, Kumar S, Lombard D, Neamati N
Eur J Med Chem
. 2022 Aug;
241:114623.
PMID: 35932566
The sirtuin deacetylase SIRT5 plays important roles in regulating multiple metabolic pathways, and potentially represents an attractive target for the treatment of several human diseases, especially cancer. In this study,...
5.
Samanta S, Yang S, Debnath B, Xue D, Kuang Y, Ramkumar K, et al.
Cancer Res
. 2021 Feb;
81(7):1883-1895.
PMID: 33531374
GRP78 (glucose-regulated protein, 78 kDa) is a key regulator of endoplasmic reticulum (ER) stress signaling. Cancer cells are highly proliferative and have high demand for protein synthesis and folding, which...
6.
Huddle B, Grimley E, Chtcherbinine M, Buchman C, Takahashi C, Debnath B, et al.
Eur J Med Chem
. 2020 Dec;
211:113060.
PMID: 33341649
There is strong evidence that inhibition of one or more Aldehyde Dehydrogenase 1A (ALDH1A) isoforms may be beneficial in chemotherapy-resistant ovarian cancer and other tumor types. While many previous efforts...
7.
Huddle B, Grimley E, Buchman C, Chtcherbinine M, Debnath B, Mehta P, et al.
J Med Chem
. 2018 Sep;
61(19):8754-8773.
PMID: 30221940
Aldehyde dehydrogenase (ALDH) activity is commonly used as a marker to identify cancer stem-like cells. The three ALDH1A isoforms have all been individually implicated in cancer stem-like cells and in...
8.
Dai W, Chen W, Debnath B, Wu Y, Neamati N
ChemMedChem
. 2018 Mar;
13(9):916-930.
PMID: 29493096
Herein we describe the synthesis and structure-activity relationships of 3-aminocyclohex-2-en-1-one derivatives as novel chemokine receptor 2 (CXCR2) antagonists. Thirteen out of 44 derivatives were found to inhibit CXCR2 downstream signaling...
9.
Mehanna W, Lu T, Debnath B, Lasheen D, Serya R, Abouzid K, et al.
ChemMedChem
. 2017 May;
12(13):1045-1054.
PMID: 28544630
Herein we describe the synthesis and biological evaluation of a series of novel benzothiazoles based on a diaryl urea scaffold previously reported in some allosteric chemokine receptor 2 (CXCR2) inhibitors....
10.
Ha H, Debnath B, Neamati N
Theranostics
. 2017 May;
7(6):1543-1588.
PMID: 28529637
The chemokine receptors CXCR1/2 and their ligand CXCL8 are essential for the activation and trafficking of inflammatory mediators as well as tumor progression and metastasis. The CXCL8-CXCR1/2 signaling axis is...