Bianca Plouffe
Overview
Explore the profile of Bianca Plouffe including associated specialties, affiliations and a list of published articles.
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32
Citations
956
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Recent Articles
1.
Hahn H, Daly C, Little 4th J, Perry-Hauser N, Flores-Espinoza E, Inoue A, et al.
Elife
. 2025 Feb;
13.
PMID: 39992711
Chemokine receptors are GPCRs that regulate the chemotactic migration of a wide variety of cells including immune and cancer cells. Most chemokine receptors contain features associated with the ability to...
2.
Ding T, Guseinov A, Milligan G, Plouffe B, Tikhonova I
ACS Pharmacol Transl Sci
. 2024 Aug;
7(8):2516-2526.
PMID: 39144548
We applied our previously developed probe confined dynamic mapping protocol, which combines enhanced sampling molecular dynamics (MD) simulations and fragment-based approaches, to identify the binding site of GSK2239633A (-[[3-[[3-[(5-chlorothiophen-2-yl)sulfonylamino]-4-methoxyindazol-1-yl]methyl]phenyl]methyl]-2-hydroxy-2-methylpropanamide), a...
3.
Saha S, Khanppnavar B, Maharana J, Kim H, Carino C, Daly C, et al.
Cell
. 2024 Aug;
187(17):4751-4769.e25.
PMID: 39089252
The Duffy antigen receptor is a seven-transmembrane (7TM) protein expressed primarily at the surface of red blood cells and displays strikingly promiscuous binding to multiple inflammatory and homeostatic chemokines. It...
4.
Daly C, Guseinov A, Hahn H, Wright A, Tikhonova I, Thomsen A, et al.
Elife
. 2023 Oct;
12.
PMID: 37855711
The vasopressin type 2 receptor (VR) is an essential G protein-coupled receptor (GPCR) in renal regulation of water homeostasis. Upon stimulation, the VR activates Gα and Gα, which is followed...
5.
Daly C, Plouffe B
Br J Pharmacol
. 2023 Sep;
PMID: 37740273
G-protein-coupled receptors (GPCRs) constitute the largest family of membrane receptors, and are involved in the transmission of a variety of extracellular stimuli such as hormones, neurotransmitters, light and odorants into...
6.
Daly C, Guseinov A, Hahn H, Wright A, Tikhonova I, Thomsen A, et al.
bioRxiv
. 2023 Apr;
PMID: 37034816
The vasopressin type 2 receptor (VR) is an essential GPCR in renal regulation of water homeostasis. Upon stimulation, the VR activates Gα and Gα, which is followed by robust recruitment...
7.
Plouffe B, Karamitri A, Flock T, Gallion J, Houston S, Daly C, et al.
ACS Pharmacol Transl Sci
. 2022 Jul;
5(2):89-101.
PMID: 35846981
G protein-coupled receptors (GPCRs) can engage distinct subsets of signaling pathways, but the structural determinants of this functional selectivity remain elusive. The naturally occurring genetic variants of GPCRs, selectively affecting...
8.
Heydenreich F, Plouffe B, Rizk A, Milic D, Zhou J, Breton B, et al.
Mol Pharmacol
. 2022 Jul;
102(3):139-149.
PMID: 35779859
Activation of G protein-coupled receptors by agonists may result in the activation of one or more G proteins and recruitment of arrestins. The extent of the activation of each of...
9.
Hegron A, Huh E, Deupi X, Sokrat B, Gao W, Le Gouill C, et al.
ACS Pharmacol Transl Sci
. 2021 Oct;
4(5):1614-1627.
PMID: 34661078
Melatonin is a hormone mainly produced by the pineal gland and MT is one of the two G protein-coupled receptors (GPCRs) mediating its action. Despite an increasing number of available...
10.
Brouwers B, Mendes de Oliveira E, Marti-Solano M, Monteiro F, Laurin S, Keogh J, et al.
Cell Rep
. 2021 Mar;
34(12):108862.
PMID: 33761344
The Melanocortin-4 Receptor (MC4R) plays a pivotal role in energy homeostasis. We used human MC4R mutations associated with an increased or decreased risk of obesity to dissect mechanisms that regulate...