Bhargav A Patel
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Explore the profile of Bhargav A Patel including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
163
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Recent Articles
1.
Dou X, Guo H, DAmico T, Abdallah L, Subramanian C, Patel B, et al.
Chemistry
. 2023 Mar;
29(29):e202300262.
PMID: 36867738
Cruentaren A is a natural product that exhibits potent antiproliferative activity against various cancer cell lines, yet its binding site within ATP synthase remained unknown, thus limiting the development of...
2.
Byun J, Lee S, Moon E, Park M, Jang H, Weitzel D, et al.
Br J Cancer
. 2023 Feb;
128(8):1491-1502.
PMID: 36759727
Background: Chaperon-mediated autophagy (CMA) has taken on a new emphasis in cancer biology. However, the roles of CMA in hypoxic tumours are poorly understood. We investigated the anti-tumour effects of...
3.
Dou X, Patel B, DAmico T, Subramanian C, Cousineau E, Yi Y, et al.
J Org Chem
. 2022 Jul;
87(15):9940-9956.
PMID: 35894845
The 90 kDa heat shock protein (Hsp90) belongs to a group of molecular chaperones that regulate homeostasis via the folding of nascent polypeptides into their biologically active proteins, many of...
4.
Velagapudi U, Patel B, Shao X, Pathak S, Ferraris D, Talele T
Expert Opin Ther Pat
. 2021 Feb;
31(7):609-623.
PMID: 33554679
Introduction: Discovery of small molecules that impede the activity of single-strand DNA repair enzyme, PARP1, has led to four marketed drugs for the treatment of advanced-stage cancers. Hence, there is...
5.
Patel B, DAmico T, Blagg B
Eur J Med Chem
. 2020 Sep;
207:112779.
PMID: 32942072
FF ATP synthase is responsible for the production of >95% of all ATP synthesis within the cell. Dysregulation of its expression, activity or localization is linked to various human diseases...
6.
Velagapudi U, Langelier M, Delgado-Martin C, Diolaiti M, Bakker S, Ashworth A, et al.
J Med Chem
. 2019 May;
62(11):5330-5357.
PMID: 31042381
Poly(adenosine 5'-diphosphate-ribose) polymerase (PARP) inhibitors are a class of anticancer drugs that block the catalytic activity of PARP proteins. Optimization of our lead compound 1 (( Z)-2-benzylidene-3-oxo-2,3-dihydrobenzofuran-7-carboxamide; PARP-1 IC =...
7.
Patel B, Abel B, Barbuti A, Velagapudi U, Chen Z, Ambudkar S, et al.
J Med Chem
. 2017 Dec;
61(3):834-864.
PMID: 29251928
A novel set of 64 analogues based on our lead compound 1 was designed and synthesized with an initial objective of understanding the structural requirements of ligands binding to a...
8.
Zhang H, Patel A, Wang Y, Zhang Y, Kathawala R, Qiu L, et al.
Mol Cancer Ther
. 2017 Mar;
16(6):1021-1030.
PMID: 28265007
Paclitaxel is one of the most widely used antineoplastic drugs in the clinic. Unfortunately, the occurrence of cellular resistance has limited its efficacy and application. The ATP-binding cassette subfamily B...
9.
Wang Y, Patel B, Anreddy N, Zhang Y, Zhang G, Alqahtani S, et al.
Sci Rep
. 2017 Feb;
7:42106.
PMID: 28181548
Multidrug resistance (MDR) attenuates the chemotherapy efficacy and increases the probability of cancer recurrence. The accelerated drug efflux mediated by ATP-binding cassette (ABC) transporters is one of the major MDR...
10.
Abdelkhalek A, Ashby Jr C, Patel B, Talele T, Seleem M
PLoS One
. 2016 Oct;
11(10):e0164227.
PMID: 27711156
Bacterial infections present a serious challenge to healthcare practitioners due to the emergence of resistance to numerous conventional antibacterial drugs. Therefore, new bacterial targets and new antimicrobials are unmet medical...