Suresh V Ambudkar
Overview
Explore the profile of Suresh V Ambudkar including associated specialties, affiliations and a list of published articles.
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Articles
246
Citations
8278
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Recent Articles
1.
Sajid A, Ranganathan N, Guha R, Murakami M, Ahmed S, Durell S, et al.
J Mol Biol
. 2025 Feb;
437(7):168979.
PMID: 39900286
The multidrug transporter P-glycoprotein (P-gp), is pivotal in exporting various chemically dissimilar amphipathic compounds including anti-cancer drugs, thus causing multidrug resistance during cancer treatment. P-gp is composed of two transmembrane...
2.
Thomas J, Frye W, Robey R, Warner A, Butcher D, Matta J, et al.
Fluids Barriers CNS
. 2025 Jan;
22(1):2.
PMID: 39754251
No abstract available.
3.
Li Y, Lin B, Murakami M, Wu Y, Hung T, Chen C, et al.
Eur J Pharmacol
. 2024 Dec;
988():177231.
PMID: 39725134
Multidrug resistance (MDR) remains a significant obstacle in cancer treatment, primarily attributable to the overexpression of ATP-binding cassette (ABC) transporters such as ABCB1 and ABCG2 within cancer cells. These transporters...
4.
Li Y, Lee Y, Murakami M, Huang Y, Hung T, Wu Y, et al.
Biomed Pharmacother
. 2024 Oct;
180:117554.
PMID: 39405897
Chemotherapy treatment faces a major obstacle with the emergence of multidrug resistance (MDR), often attributed to the elevated expression of ATP-binding cassette (ABC) transporters such as ABCG2 and ABCB1 in...
5.
Lin B, Li Y, Murakami M, Wu Y, Huang Y, Hung T, et al.
Biomed Pharmacother
. 2024 Oct;
180:117542.
PMID: 39388999
A significant hurdle in cancer treatment arises from multidrug resistance (MDR), often due to overexpression of ATP-binding cassette (ABC) transporters like ABCB1 and/or ABCG2 in cancer cells. These transporters actively...
6.
Salazar P, Murakami M, Ranganathan N, Durell S, Ambudkar S
Protein Sci
. 2024 Aug;
33(9):e5155.
PMID: 39194126
Human P-glycoprotein (P-gp) utilizes energy from ATP hydrolysis for the efflux of chemically dissimilar amphipathic small molecules and plays an important role in the development of resistance to chemotherapeutic agents...
7.
Lu Q, Ambudkar S, Yang D
Drug Resist Updat
. 2024 Aug;
77:101135.
PMID: 39178712
No abstract available.
8.
Rahman I, Liang B, Sajid A, Ambudkar S, Huang H
Photochem Photobiol
. 2024 Jun;
101(1):188-205.
PMID: 38824410
P-glycoprotein (P-gp, ABCB1) is a well-researched ATP-binding cassette (ABC) drug efflux transporter linked to the development of cancer multidrug resistance (MDR). Despite extensive studies, approved therapies to safely inhibit P-gp...
9.
Wu C, Hung C, Murakami M, Wu Y, Chu Y, Huang Y, et al.
Int J Mol Sci
. 2024 May;
25(10).
PMID: 38791198
MTX-211 is a first-in-class dual inhibitor of epidermal growth factor receptor (EGFR) and phosphoinositide-3 kinase (PI3K) signaling pathways with a compelling pharmaceutical profile and could enhance the effectiveness of mitogen-activated...
10.
da Silva Zanzarini I, Henrique Kita D, Scheiffer G, Karoline Dos Santos K, de Paula Dutra J, Augusto Pastore M, et al.
Bioorg Chem
. 2024 Mar;
146:107283.
PMID: 38513324
The breast cancer resistance protein (BCRP/ABCG2) transporter mediates the efflux of numerous antineoplastic drugs, playing a central role in multidrug resistance related to cancer. The absence of successful clinical trials...