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Bertrand Z Yeung

Explore the profile of Bertrand Z Yeung including associated specialties, affiliations and a list of published articles. Areas
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Articles 17
Citations 1161
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Recent Articles
1.
Chung H, Parkhurst C, Magee E, Phillips D, Habibi E, Chen F, et al.
Nat Methods . 2021 Oct; 18(10):1204-1212. PMID: 34608310
Identifying gene-regulatory targets of nuclear proteins in tissues is a challenge. Here we describe intranuclear cellular indexing of transcriptomes and epitopes (inCITE-seq), a scalable method that measures multiplexed intranuclear protein...
2.
Hwang B, Lee D, Tamaki W, Sun Y, Ogorodnikov A, Hartoularos G, et al.
Nat Methods . 2021 Aug; 18(8):903-911. PMID: 34354295
The development of DNA-barcoded antibodies to tag cell surface molecules has enabled the use of droplet-based single-cell sequencing (dsc-seq) to profile protein abundances from thousands of cells simultaneously. As compared...
3.
Wang J, Yeung B, Wientjes M, Cui M, Peer C, Lu Z, et al.
Pharmaceutics . 2021 Jul; 13(7). PMID: 34209265
Exosomes, naturally occurring vesicles secreted by cells, are undergoing development as drug carriers. We used experimental and computational studies to investigate the kinetics of intracellular exosome processing and exosome-mediated drug...
4.
Mimitou E, Lareau C, Chen K, Zorzetto-Fernandes A, Hao Y, Takeshima Y, et al.
Nat Biotechnol . 2021 Jun; 39(10):1246-1258. PMID: 34083792
Recent technological advances have enabled massively parallel chromatin profiling with scATAC-seq (single-cell assay for transposase accessible chromatin by sequencing). Here we present ATAC with select antigen profiling by sequencing (ASAP-seq),...
5.
Wu S, Roden D, Al-Eryani G, Bartonicek N, Harvey K, Cazet A, et al.
Genome Med . 2021 May; 13(1):81. PMID: 33971952
Background: High throughput single-cell RNA sequencing (scRNA-Seq) has emerged as a powerful tool for exploring cellular heterogeneity among complex human cancers. scRNA-Seq studies using fresh human surgical tissue are logistically...
6.
Papalexi E, Mimitou E, Butler A, Foster S, Bracken B, Mauck 3rd W, et al.
Nat Genet . 2021 Mar; 53(3):322-331. PMID: 33649593
The expression of inhibitory immune checkpoint molecules, such as programmed death-ligand (PD-L)1, is frequently observed in human cancers and can lead to the suppression of T cell-mediated immune responses. Here,...
7.
Arunachalam P, Charles T, Joag V, Bollimpelli V, Scott M, Wimmers F, et al.
Nat Med . 2020 May; 26(6):932-940. PMID: 32393800
Recent efforts toward an HIV vaccine focus on inducing broadly neutralizing antibodies, but eliciting both neutralizing antibodies (nAbs) and cellular responses may be superior. Here, we immunized macaques with an...
8.
Stoeckius M, Zheng S, Houck-Loomis B, Hao S, Yeung B, Mauck 3rd W, et al.
Genome Biol . 2018 Dec; 19(1):224. PMID: 30567574
Despite rapid developments in single cell sequencing, sample-specific batch effects, detection of cell multiplets, and experimental costs remain outstanding challenges. Here, we introduce Cell Hashing, where oligo-tagged antibodies against ubiquitously...
9.
Jaiprasart P, Yeung B, Lu Z, Wientjes M, Cui M, Hsieh C, et al.
J Control Release . 2017 Dec; 270:101-113. PMID: 29203416
RNA Interference (RNAi) is a potentially useful tool to correct the detrimental effects of faulty genes; several RNAi are undergoing clinical evaluation in various diseases. The present study identified the...
10.
Wang J, Yeung B, Cui M, Peer C, Lu Z, Figg W, et al.
J Control Release . 2017 Oct; 268:147-158. PMID: 29054369
Purpose: Exosomes are small membrane vesicles (30-100nm in diameter) secreted by cells into extracellular space. The present study evaluated the effect of chemotherapeutic agents on exosome production and/or release, and...