Benjamin T Walters
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Explore the profile of Benjamin T Walters including associated specialties, affiliations and a list of published articles.
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26
Citations
949
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Recent Articles
11.
Maun H, Jackman J, Choy D, Loyet K, Staton T, Jia G, et al.
Cell
. 2020 Jan;
180(2):406.
PMID: 31978350
No abstract available.
12.
Maun H, Jackman J, Choy D, Loyet K, Staton T, Jia G, et al.
Cell
. 2019 Oct;
179(2):417-431.e19.
PMID: 31585081
Severe asthma patients with low type 2 inflammation derive less clinical benefit from therapies targeting type 2 cytokines and represent an unmet need. We show that mast cell tryptase is...
13.
Holliday M, Witt A, Gama A, Walters B, Arthur C, Halfmann R, et al.
Nat Commun
. 2019 Jul;
10(1):3070.
PMID: 31296852
CARD9 and CARD11 drive immune cell activation by nucleating Bcl10 polymerization, but are held in an autoinhibited state prior to stimulation. Here, we elucidate the structural basis for this autoinhibition...
14.
Masson G, Burke J, Ahn N, Anand G, Borchers C, Brier S, et al.
Nat Methods
. 2019 Jun;
16(7):595-602.
PMID: 31249422
Hydrogen deuterium exchange mass spectrometry (HDX-MS) is a powerful biophysical technique being increasingly applied to a wide variety of problems. As the HDX-MS community continues to grow, adoption of best...
15.
Hudgens J, Gallagher E, Karageorgos I, Anderson K, Filliben J, Huang R, et al.
Anal Chem
. 2019 May;
91(11):7336-7345.
PMID: 31045344
Hydrogen-deuterium exchange mass spectrometry (HDX-MS) is an established, powerful tool for investigating protein-ligand interactions, protein folding, and protein dynamics. However, HDX-MS is still an emergent tool for quality control of...
16.
Moorthy B, E Zarraga I, Kumar L, Walters B, Goldbach P, Topp E, et al.
Mol Pharm
. 2017 Nov;
15(1):1-11.
PMID: 29182876
Solid state hydrogen-deuterium exchange with mass spectrometric analysis (ssHDX-MS) has been used to assess protein conformation and matrix interactions in lyophilized solids. ssHDX-MS metrics have been previously correlated to the...
17.
Lei M, Carcelen T, Walters B, Zamiri C, Quan C, Hu Y, et al.
Anal Chem
. 2017 Jun;
89(13):7225-7231.
PMID: 28585810
Light is known to induce covalently linked aggregates in proteins. These aggregates can be immunogenic and are of concern for drug product development in the biotechnology industry. Histidine (His) is...
18.
Koenig P, Lee C, Walters B, Janakiraman V, Stinson J, Patapoff T, et al.
Proc Natl Acad Sci U S A
. 2017 Jan;
114(4):E486-E495.
PMID: 28057863
Somatic mutations within the antibody variable domains are critical to the immense capacity of the immune repertoire. Here, via a deep mutational scan, we dissect how mutations at all positions...
19.
Walters B
Anal Chem
. 2016 Dec;
89(2):1049-1053.
PMID: 28024318
Amide hydrogen exchange experiments measured by mass spectrometry have become commonplace to study protein structural dynamics; however, the underdetermined nature of these measurements render extraction of exchange rates unreliable at...
20.
Walters B, Jensen P, Larraillet V, Lin K, Patapoff T, Schlothauer T, et al.
J Biol Chem
. 2015 Dec;
291(4):1817-1825.
PMID: 26627822
Crystallographic evidence suggests that the pH-dependent affinity of IgG molecules for the neonatal Fc receptor (FcRn) receptor primarily arises from salt bridges involving IgG histidine residues, resulting in moderate affinity...