Henry R Maun
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Explore the profile of Henry R Maun including associated specialties, affiliations and a list of published articles.
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21
Citations
599
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Recent Articles
1.
Chavarria-Smith J, Chiu C, Jackman J, Yin J, Zhang J, Hackney J, et al.
Sci Transl Med
. 2022 Dec;
14(675):eabp9159.
PMID: 36516271
The epidermis is a barrier that prevents water loss while keeping harmful substances from penetrating the host. The impermeable cornified layer of the stratum corneum is maintained by balancing continuous...
2.
Jackman J, Stockwell A, Choy D, Xie M, Lu P, Jia G, et al.
J Allergy Clin Immunol
. 2022 Apr;
150(4):972-978.e7.
PMID: 35487308
Background: Clinical studies of type 2 (T2) cytokine-related neutralizing antibodies in asthma have identified a substantial subset of patients with low levels of T2 inflammation who do not benefit from...
3.
Maun H, Vij R, Walters B, Morando A, Jackman J, Wu P, et al.
Nat Commun
. 2020 Dec;
11(1):6435.
PMID: 33353951
Human β-tryptase, a tetrameric trypsin-like serine protease, is an important mediator of allergic inflammatory responses in asthma. Antibodies generally inhibit proteases by blocking substrate access by binding to active sites...
4.
Sperinde G, Bremer M, Maun H, Baruch A, Lazarus R, Koerber J, et al.
Bioanalysis
. 2020 Sep;
12(19):1377-1388.
PMID: 32975431
Tryptase is a tetrameric trypsin-like serine protease contained within the secretory granules of mast cells and is an important mediator of allergic inflammatory responses in respiratory diseases. Detection of active...
5.
Maun H, Jackman J, Choy D, Loyet K, Staton T, Jia G, et al.
Cell
. 2020 Jan;
180(2):406.
PMID: 31978350
No abstract available.
6.
Maun H, Jackman J, Choy D, Loyet K, Staton T, Jia G, et al.
Cell
. 2019 Oct;
179(2):417-431.e19.
PMID: 31585081
Severe asthma patients with low type 2 inflammation derive less clinical benefit from therapies targeting type 2 cytokines and represent an unmet need. We show that mast cell tryptase is...
7.
Maun H, Liu P, Franke Y, Eigenbrot C, Forrest W, Schwartz L, et al.
J Biol Chem
. 2018 Apr;
293(25):9614-9628.
PMID: 29661938
Human β-tryptase, a tetrameric trypsin-like serine protease, is an important mediator of the allergic inflammatory responses in asthma. During acute hypersensitivity reactions, mast cells degranulate, releasing active tetramer as a...
8.
Landgraf K, Steffek M, Quan C, Tom J, Yu C, Santell L, et al.
Nat Chem Biol
. 2014 May;
10(7):567-73.
PMID: 24859116
Stimulation of hepatocyte growth factor (HGF) signaling through the Met receptor is an attractive approach for promoting tissue repair and preventing fibrosis. Using structure-guided peptide phage display combined with an...
9.
Kauder S, Santell L, Mai E, Wright L, Luis E, NDiaye E, et al.
PLoS One
. 2014 Jan;
8(12):e83958.
PMID: 24409221
Background: Macrophage stimulating protein (MSP) is a serum growth factor that binds to and activates the receptor tyrosine kinase, Recepteur d'Origine Nantais (RON). A non-synonymous coding variant in MSP (689C)...
10.
Merchant M, Ma X, Maun H, Zheng Z, Peng J, Romero M, et al.
Proc Natl Acad Sci U S A
. 2013 Jul;
110(32):E2987-96.
PMID: 23882082
Binding of hepatocyte growth factor (HGF) to the receptor tyrosine kinase MET is implicated in the malignant process of multiple cancers, making disruption of this interaction a promising therapeutic strategy....