Benjamin M Johnson
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Explore the profile of Benjamin M Johnson including associated specialties, affiliations and a list of published articles.
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Articles
38
Citations
536
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Recent Articles
21.
Luo G, Chen L, Conway C, Kostich W, Johnson B, Ng A, et al.
J Org Chem
. 2017 Mar;
82(7):3710-3720.
PMID: 28306261
An asymmetric synthesis of the major metabolite of the calcitonin gene-related peptide recepotor antagonist BMS-846372 is presented. The variously substituted cyclohepta[b]pyridine ring system represents an underexplored ring system and showed...
22.
Li W, Zhao W, Liu X, Huang X, Lopez O, Leet J, et al.
Drug Metab Dispos
. 2016 Apr;
44(6):809-20.
PMID: 27029743
Daclatasvir is a first-in-class, potent, and selective inhibitor of the hepatitis C virus nonstructural protein 5A replication complex. In support of nonclinical studies during discovery and exploratory development, liquid chromatography-tandem...
23.
Zhuo X, Cantone J, Wang Y, Leet J, Drexler D, Yeung K, et al.
Drug Metab Dispos
. 2016 Mar;
44(8):1332-1340.
PMID: 26961241
During a medicinal chemistry campaign to identify inhibitors of the hepatitis C virus nonstructural protein 5B (RNA-dependent RNA polymerase), a bicyclo[1.1.1]pentane was introduced into the chemical scaffold to improve metabolic...
24.
Sun J, OBoyle 2nd D, Fridell R, Langley D, Wang C, Roberts S, et al.
Nature
. 2015 Nov;
527(7577):245-8.
PMID: 26536115
It is estimated that more than 170 million people are infected with hepatitis C virus (HCV) worldwide. Clinical trials have demonstrated that, for the first time in human history, the...
25.
Sofi M, Johnson B, Gudi R, Wolf K, Lorenz R, Vasu C
Diabetes
. 2015 Jul;
64(8):e20-1.
PMID: 26207043
No abstract available.
26.
Zhuo X, Huang X, Degnan A, Snyder L, Yang F, Huang H, et al.
Drug Metab Dispos
. 2015 Jan;
43(4):578-89.
PMID: 25633841
A recent medicinal chemistry campaign to identify positive allosteric modulators (PAMs) of metabotropic glutamate receptor subtype 5 (mGluR5) led to the discovery of potent compounds featuring an oxazolidinone structural core...
27.
Karumuthil-Melethil S, Sofi M, Gudi R, Johnson B, Perez N, Vasu C
Diabetes
. 2014 Nov;
64(4):1341-57.
PMID: 25377877
The progression of autoimmune diseases is dictated by deviations in the fine balance between proinflammatory versus regulatory responses, and pathogen recognition receptors (PRRs) play a key role in maintaining this...
28.
Sinha S, Ahire D, Wagh S, Mullick D, Sistla R, Selvakumar K, et al.
Chem Res Toxicol
. 2014 Nov;
27(12):2052-61.
PMID: 25372409
Certain aromatic nitriles are well-known inhibitors of cysteine proteases. The mode of action of these compounds involves the formation of a reversible or irreversible covalent bond between the nitrile and...
29.
Karumuthil-Melethil S, Gudi R, Johnson B, Perez N, Vasu C
J Immunol
. 2014 Aug;
193(7):3308-21.
PMID: 25143443
β-Glucans are naturally occurring polysaccharides in cereal grains, mushrooms, algae, or microbes, including bacteria, fungi, and yeast. Immune cells recognize these β-glucans through a cell surface pathogen recognition receptor called...
30.
Johnson B, Doonan B, Radwan F, Haque A
Open Prost Cancer J
. 2014 May;
3:78-85.
PMID: 24790681
Prostate cancer is the most commonly diagnosed cancer in men and accounts for significant morbidity and mortality in the western world. While traditional therapies are effective at clearing early stage...