Benjamin M Johnson
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Explore the profile of Benjamin M Johnson including associated specialties, affiliations and a list of published articles.
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38
Citations
536
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Recent Articles
11.
Johnson B, Shu Y, Zhuo X, Meanwell N
J Med Chem
. 2020 Mar;
63(12):6315-6386.
PMID: 32182061
The applications of fluorine in drug design continue to expand, facilitated by an improved understanding of its effects on physicochemical properties and the development of synthetic methodologies that are providing...
12.
Johnson B, Gaudreau M, Gudi R, Brown R, Gilkeson G, Vasu C
J Autoimmun
. 2020 Feb;
108:102420.
PMID: 32019684
The risk of developing systemic lupus erythematosus (SLE) is about 9 times higher in women as compared to men. Our recent report, which used (SWRxNZB) F1 (SNF1) mouse model of...
13.
Gudi R, Suber J, Brown R, Johnson B, Vasu C
J Nutr
. 2019 Dec;
150(5):1291-1302.
PMID: 31879786
Background: β-Glucans (BGs), a group of complex dietary polysaccharides (CDPs), are available as dietary supplements. However, the effects of orally administered highly purified BGs on gut inflammation are largely unknown....
14.
OMalley D, Ahuja V, Fink B, Cao C, Wang C, Swanson J, et al.
ACS Med Chem Lett
. 2019 Oct;
10(10):1486-1491.
PMID: 31620238
C-terminal Src kinase (CSK) functions as a negative regulator of T cell activation through inhibitory phosphorylation of LCK, so inhibitors of CSK are of interest as potential immuno-oncology agents. Screening...
15.
Sofi M, Johnson B, Gudi R, Jolly A, Gaudreau M, Vasu C
Diabetes
. 2019 Jul;
68(10):1975-1989.
PMID: 31311801
(BF) is an integral component of the human colonic commensal microbiota. BF is also the most commonly isolated organism from clinical cases of intra-abdominal abscesses, suggesting its potential to induce...
16.
Patil A, Ladumor M, Kamble S, Johnson B, Subramanian M, Sinz M, et al.
Xenobiotica
. 2019 Feb;
49(12):1403-1413.
PMID: 30747549
1. Terbinafine (TBF), a common antifungal agent, has been associated with rare incidences of hepatotoxicity. It is hypothesized that bioactivation of TBF to reactive intermediates and subsequent binding to critical...
17.
Gudi R, Perez N, Johnson B, Sofi M, Brown R, Quan S, et al.
Immunology
. 2019 Feb;
157(1):70-85.
PMID: 30712258
The dietary supplement and prebiotic values of β-glucan-rich products have been widely recognized and dietary approaches for modulating autoimmunity have been increasingly explored, we assess the impact of oral administration...
18.
Johnson B, Radwan F, Hossain A, Doonan B, Hathaway-Schrader J, God J, et al.
J Cell Biochem
. 2018 Nov;
120(4):6264-6276.
PMID: 30378157
Though the current therapies are effective at clearing an early stage prostate cancer, they often fail to treat late-stage metastatic disease. We aimed to investigate the molecular mechanisms underlying the...
19.
Zhuo X, Wang Y, Yeung K, Zhu J, Huang X, Parcella K, et al.
Xenobiotica
. 2017 Nov;
48(12):1215-1226.
PMID: 29182424
1. Due to its unique C-C and C-H bonding properties, conformational preferences and relative hydrophilicity, the cyclopropyl ring has been used as a synthetic building block in drug discovery to...
20.
Paiva A, Klakouski C, Li S, Johnson B, Shu Y, Josephs J, et al.
Bioanalysis
. 2017 Mar;
9(7):541-552.
PMID: 28339283
Aim: High clearance is a commonly encountered issue in drug discovery. Here we present a centralized metabolic soft spot identification assay with adequate capacity and turnaround time to support the...