Benjamin M Johnson
Overview
Explore the profile of Benjamin M Johnson including associated specialties, affiliations and a list of published articles.
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Articles
38
Citations
536
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Recent Articles
1.
Donnelly D, Kim J, Tran T, Scola P, Tenney D, Pena A, et al.
Eur J Nucl Med Mol Imaging
. 2023 Dec;
51(4):978-990.
PMID: 38049658
Purpose: A same-day PET imaging agent capable of measuring PD-L1 status in tumors is an important tool for optimizing PD-1 and PD-L1 treatments. Herein we describe the discovery and evaluation...
2.
Gudi R, Johnson B, Gaudreau M, Sun W, Ball L, Vasu C
Immunology
. 2023 Nov;
171(2):235-249.
PMID: 37947218
The incidence of systemic lupus erythematosus (SLE) is about nine times higher in women than in men, and the underlying mechanisms that contribute to this gender bias are not fully...
3.
Zhuo X, Howell B, Shen H, Woodhead J, Mosure K, Zhang Y, et al.
Toxicol Sci
. 2023 Jun;
194(2):235-245.
PMID: 37261863
BMS-932481 was designed to modulate ɣ-secretase activity to produce shorter and less amyloidogenic peptides, potentially averting liabilities associated with complete enzymatic inhibition. Although it demonstrated the intended pharmacology in the...
4.
Luo G, Chen L, Kostich W, Hamman B, Allen J, Easton A, et al.
J Med Chem
. 2022 Mar;
65(6):4534-4564.
PMID: 35261239
Recent mouse knockout studies identified adapter protein-2-associated kinase 1 (AAK1) as a viable target for treating neuropathic pain. BMS-986176/LX-9211 (), as a highly selective, CNS-penetrable, and potent AAK1 inhibitor, has...
5.
Luo G, Chen L, Kostich W, Hamman B, Allen J, Easton A, et al.
J Med Chem
. 2022 Mar;
65(6):4457-4480.
PMID: 35257579
Recent mouse knockout studies identified adapter protein-2 associated kinase 1 (AAK1) as a viable target for treating neuropathic pain. Potent small-molecule inhibitors of AAK1 have been identified and show efficacy...
6.
Gaudreau M, Gudi R, Li G, Johnson B, Vasu C
Autoimmunity
. 2021 Dec;
55(2):95-108.
PMID: 34882054
Progressive destruction of pancreatic islet β-cells by immune cells is a primary feature of type 1 diabetes (T1D) and therapies that can restore the functional β-cell mass are needed to...
7.
Degnan A, Kumi G, Allard C, Araujo E, Johnson W, Zimmermann K, et al.
ACS Med Chem Lett
. 2021 Mar;
12(3):443-450.
PMID: 33732413
While the discovery of immune checkpoint inhibitors has led to robust, durable responses in a range of cancers, many patients do not respond to currently available therapeutics. Therefore, an urgent...
8.
You D, Hillerman S, Locke G, Chaudhry C, Stromko C, Murtaza A, et al.
J Immunother Cancer
. 2021 Jan;
9(1).
PMID: 33408094
Background: Hematopoietic progenitor kinase 1 (HPK1 or MAP4K1) has been demonstrated as a negative intracellular immune checkpoint in mediating antitumor immunity in studies with HPK1 knockout and kinase dead mice....
9.
Zhang Y, Boy K, Wu Y, Ramirez A, Toyn J, Ahlijanian M, et al.
Bioorg Med Chem Lett
. 2020 Sep;
30(22):127530.
PMID: 32890687
In an effort to improve physical properties by introducing polar functionality into the bicyclic pyrimidine gamma-secretase modulator (GSM) clinical candidate BMS-932481, we prepared several oxidative products of BMS-932481. Among the...
10.
Sun W, Gudi R, Johnson B, Vasu C
Sci Rep
. 2020 Sep;
10(1):14258.
PMID: 32868790
Our recent studies, using (SWRxNZB)F1 (SNF1) mice, showed a potential contribution of the gut microbiota and pro-inflammatory immune responses of the gut mucosa to systemic autoimmunity in lupus. Here, using...