Benjamin J Hackel
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Explore the profile of Benjamin J Hackel including associated specialties, affiliations and a list of published articles.
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87
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1690
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Recent Articles
11.
Hassler J, Lawson M, Arroyo E, Bates F, Hackel B, Lodge T
Langmuir
. 2023 Sep;
39(40):14263-14274.
PMID: 37755825
Poloxamers, a class of biocompatible, commercially available amphiphilic block polymers (ABPs) comprising poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO) blocks, interact with phospholipid bilayers, resulting in altered mechanical and surface...
12.
Golinski A, Schmitz Z, Nielsen G, Johnson B, Saha D, Appiah S, et al.
ACS Synth Biol
. 2023 Aug;
12(9):2600-2615.
PMID: 37642646
Engineered proteins have emerged as novel diagnostics, therapeutics, and catalysts. Often, poor protein developability─quantified by expression, solubility, and stability─hinders utility. The ability to predict protein developability from amino acid sequence...
13.
McConnell A, Hackel B
Cell Syst
. 2023 Jul;
14(8):656-666.
PMID: 37494931
Discovery and evolution of new and improved proteins has empowered molecular therapeutics, diagnostics, and industrial biotechnology. Discovery and evolution both require efficient screens and effective libraries, although they differ in...
14.
Hahn D, Quick J, Thompson B, Crabtree A, Hackel B, Bates F, et al.
Skelet Muscle
. 2023 May;
13(1):9.
PMID: 37208786
Duchenne muscular dystrophy (DMD) is caused by the lack of dystrophin, a cytoskeletal protein essential for the preservation of the structural integrity of the muscle cell membrane. DMD patients develop...
15.
Crabtree A, Boehnke N, Bates F, Hackel B
Proc Natl Acad Sci U S A
. 2023 Apr;
120(18):e2219885120.
PMID: 37094151
Poly(ethylene oxide) (PEO) and poloxamers, a class of poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) (PEO-PPO-PEO) triblock copolymers, have many personal and medical care applications, including the stabilization of stressed cellular membranes. Despite...
16.
Vunnam N, Been M, Huber E, Paulson C, Szymonski S, Hackel B, et al.
Mol Pharm
. 2023 Mar;
20(4):1884-1897.
PMID: 36897792
Tumor necrosis factor (TNF) is a key regulator of immune responses and plays a significant role in the initiation and maintenance of inflammation. Upregulation of TNF expression leads to several...
17.
Crabtree A, Bates F, Hackel B
ACS Appl Polym Mater
. 2023 Feb;
4(5):3259-3269.
PMID: 36777189
Poloxamer 188, a poly(ethylene oxide)--poly(propylene oxide)--poly(ethylene oxide) (PEO-PPO-PEO) triblock copolymer, protects cell membranes in several injury models. However, the nature of the copolymer/membrane interaction and the mechanism of membrane protection...
18.
Bez Batti Angulski A, Cohen H, Kim M, Hahn D, Van Zee N, Lodge T, et al.
Mol Ther Methods Clin Dev
. 2023 Jan;
28:162-176.
PMID: 36654800
First-in-class membrane stabilizer Poloxamer 188 (P188) has been shown to confer membrane protection in an extensive range of clinical conditions; however, elements of the systemic distribution and localization of P188...
19.
Tresnak D, Hackel B
ACS Synth Biol
. 2023 Jan;
12(1):249-264.
PMID: 36599162
Antibiotic-resistant infectious disease is a critical challenge to human health. Antimicrobial proteins offer a compelling solution if engineered for potency, selectivity, and physiological stability. Lysins, which lyse cells via degradation...
20.
Hassler J, Crabtree A, Liberman L, Bates F, Hackel B, Lodge T
Biomacromolecules
. 2022 Dec;
24(1):449-461.
PMID: 36563027
Poloxamers─triblock copolymers consisting of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO)─have demonstrated cell membrane stabilization efficacy against numerous types of stress. However, the mechanism responsible for this stabilizing effect remains...