Daniel R Woldring
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Explore the profile of Daniel R Woldring including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
122
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Recent Articles
1.
Chen J, Woldring D, Huang F, Huang X, Wei G
Comput Biol Med
. 2023 Jul;
164:107258.
PMID: 37506452
High-throughput deep mutational scanning (DMS) experiments have significantly impacted protein engineering, drug discovery, immunology, cancer biology, and evolutionary biology by enabling the systematic understanding of protein functions. However, the mutational...
2.
Stern L, Csizmar C, Woldring D, Wagner C, Hackel B
ACS Comb Sci
. 2017 Mar;
19(5):315-323.
PMID: 28322543
Yeast surface display selections against mammalian cell monolayers have proven effective in isolating proteins with novel binding activity. Recent advances in this technique allow for the recovery of clones with...
3.
Woldring D, Holec P, Stern L, Du Y, Hackel B
Biochemistry
. 2017 Mar;
56(11):1656-1671.
PMID: 28248518
Engineered proteins provide clinically and industrially impactful molecules and utility within fundamental research, yet inefficiencies in discovering lead variants with new desired functionality, while maintaining stability, hinder progress. Improved function,...
4.
Kruziki M, Case B, Chan J, Zudock E, Woldring D, Yee D, et al.
Mol Pharm
. 2016 Oct;
13(11):3747-3755.
PMID: 27696863
This purpose of this study is to determine the efficacy of a 45-amino acid Gp2 domain, engineered to bind to epidermal growth factor receptor (EGFR), as a positron emission tomography...
5.
Woldring D, Holec P, Hackel B
Proteins
. 2016 Mar;
84(7):869-74.
PMID: 27018773
ScaffoldSeq is software designed for the numerous applications-including directed evolution analysis-in which a user generates a population of DNA sequences encoding for partially diverse proteins with related functions and would...
6.
Woldring D, Holec P, Zhou H, Hackel B
PLoS One
. 2015 Sep;
10(9):e0138956.
PMID: 26383268
Discovering new binding function via a combinatorial library in small protein scaffolds requires balance between appropriate mutations to introduce favorable intermolecular interactions while maintaining intramolecular integrity. Sitewise constraints exist in...
7.
Kruziki M, Bhatnagar S, Woldring D, Duong V, Hackel B
Chem Biol
. 2015 Jul;
22(7):946-56.
PMID: 26165154
Small protein ligands can provide superior physiological distribution compared with antibodies, and improved stability, production, and specific conjugation. Systematic evaluation of the PDB identified a scaffold to push the limits...