Benjamin J Hackel
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Explore the profile of Benjamin J Hackel including associated specialties, affiliations and a list of published articles.
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87
Citations
1690
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Recent Articles
1.
Nielsen G, Sachs J, Hackel B
Biotechnol Bioeng
. 2025 Mar;
PMID: 40045532
Protein developability is an important, yet often overlooked, aspect of protein discovery campaigns that is a key driver of utility. Recent advances have improved developability screening capacity, making it an...
2.
Torres S, Lan C, Harthorn A, Schmitz Z, Blanchard P, Collins J, et al.
Bioconjug Chem
. 2025 Mar;
PMID: 40030409
Multiple studies have demonstrated the benefit of engineering hybrid ligands that combine the unique benefits of small molecules and proteins or peptides. However, the molecular complexity of hybrid ligands generates...
3.
Harthorn A, Kuo T, Torres S, Lobb R, Hackel B
Mol Pharm
. 2024 Dec;
22(1):558-572.
PMID: 39704255
Selective delivery of therapeutic modalities to tumor cells via binding of tumor-selective cell-surface biomarkers has empowered substantial advances in cancer treatment. Yet, tumor cells generally lack a truly specific biomarker...
4.
Lopez-Morales J, Vanella R, Appelt E, Whillock S, Paulk A, Shusta E, et al.
Small Sci
. 2024 Jul;
3(12).
PMID: 39071103
Yeast surface display (YSD) is a powerful tool in biotechnology that links genotype to phenotype. In this review, the latest advancements in protein engineering and high-throughput screening based on YSD...
5.
Nielsen G, Schmitz Z, Hackel B
Protein Eng Des Sel
. 2024 Jun;
37.
PMID: 38836499
Protein developability is requisite for use in therapeutic, diagnostic, or industrial applications. Many developability assays are low throughput, which limits their utility to the later stages of protein discovery and...
6.
Collins J, Hackel B
Protein Eng Des Sel
. 2024 Mar;
37.
PMID: 38484121
Proline-rich antimicrobial peptides (PrAMPs) are attractive antibiotic candidates that target gram-negative bacteria ribosomes. We elucidated the sequence-function landscape of 43 000 variants of a recently discovered family member, Tur1a, using...
7.
Collins J, McConnell A, Schmitz Z, Hackel B
bioRxiv
. 2024 Feb;
PMID: 38352424
Antimicrobial peptides (AMPs) are essential elements of natural cellular combat and candidates as antibiotic therapy. Elevated function may be needed for robust physiological performance. Yet, both pure protein design and...
8.
Huang M, Rueda-Garcia M, Harthorn A, Hackel B, Van Deventer J
ACS Chem Biol
. 2024 Jan;
19(2):325-335.
PMID: 38230650
Protein-small molecule hybrids are structures that have the potential to combine the inhibitory properties of small molecules and the specificities of binding proteins. However, achieving such synergies is a substantial...
9.
Blanchard P, Knick B, Whelan S, Hackel B
ACS Synth Biol
. 2023 Nov;
12(12):3608-3622.
PMID: 38010428
Small, single-domain protein scaffolds are compelling sources of molecular binding ligands with the potential for efficient physiological transport, modularity, and manufacturing. Yet, mini-proteins require a balance between biophysical robustness and...
10.
McConnell A, Batten S, Hackel B
J Mol Biol
. 2023 Nov;
435(24):168339.
PMID: 37923119
Binding ligands empower molecular therapeutics and diagnostics. Despite an array of protein scaffolds engineered for binding, the biophysical elements that drive developability and evolvability are not fully understood. In particular,...