Benjamin G Hale
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Explore the profile of Benjamin G Hale including associated specialties, affiliations and a list of published articles.
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56
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2406
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Recent Articles
21.
Lanz C, Schotsaert M, Magnus C, Karakus U, Hunziker A, Sempere Borau M, et al.
J Exp Med
. 2021 Apr;
218(6).
PMID: 33882122
The disease severity of influenza is highly variable in humans, and one genetic determinant behind these differences is the IFITM3 gene. As an effector of the interferon response, IFITM3 potently...
22.
Lork M, Lieber G, Hale B
Viruses
. 2021 Apr;
13(3).
PMID: 33806893
SUMOylation is a highly dynamic ubiquitin-like post-translational modification that is essential for cells to respond to and resolve various genotoxic and proteotoxic stresses. Virus infections also constitute a considerable stress...
23.
Pohl M, Busnadiego I, Kufner V, Glas I, Karakus U, Schmutz S, et al.
PLoS Biol
. 2021 Mar;
19(3):e3001006.
PMID: 33760807
Since entering the human population, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2; the causative agent of Coronavirus Disease 2019 [COVID-19]) has spread worldwide, causing >100 million infections and >2 million...
24.
Stertz S, Hale B
Trends Microbiol
. 2021 Mar;
29(11):973-982.
PMID: 33757684
Pandemics are caused by novel pathogens to which pre-existing antibody immunity is lacking. Under these circumstances, the body must rely on innate interferon-mediated defenses to limit pathogen replication and allow...
25.
Busnadiego I, Fernbach S, Pohl M, Karakus U, Huber M, Trkola A, et al.
mBio
. 2020 Sep;
11(5).
PMID: 32913009
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), is a recently emerged respiratory coronavirus that has infected >23 million people worldwide with >800,000 deaths....
26.
Spieler E, Moritz E, Stertz S, Hale B
mSphere
. 2020 Aug;
5(4).
PMID: 32848003
Natural adaptation of an antigenically novel avian influenza A virus (IAV) to be transmitted efficiently in humans has the potential to trigger a devastating pandemic. Understanding viral genetic determinants underlying...
27.
Schmidt N, Domingues P, Golebiowski F, Patzina C, Tatham M, Hay R, et al.
Proc Natl Acad Sci U S A
. 2019 Aug;
116(35):17399-17408.
PMID: 31391303
Dynamic small ubiquitin-like modifier (SUMO) linkages to diverse cellular protein groups are critical to orchestrate resolution of stresses such as genome damage, hypoxia, or proteotoxicity. Defense against pathogen insult (often...
28.
Domingues P, Eletto D, Magnus C, Turkington H, Schmutz S, Zagordi O, et al.
Nat Commun
. 2019 Aug;
10(1):3396.
PMID: 31363119
Species' differences in cellular factors limit avian influenza A virus (IAV) zoonoses and human pandemics. The IAV polymerase, vPol, harbors evolutionary sites to overcome restriction and determines virulence. Here, we...
29.
Karakus U, Thamamongood T, Ciminski K, Ran W, Gunther S, Pohl M, et al.
Nature
. 2019 Feb;
567(7746):109-112.
PMID: 30787439
Zoonotic influenza A viruses of avian origin can cause severe disease in individuals, or even global pandemics, and thus pose a threat to human populations. Waterfowl and shorebirds are believed...
30.
Turkington H, Juozapaitis M, Tsolakos N, Corrales-Aguilar E, Schwemmle M, Hale B
J Virol
. 2017 Dec;
92(5).
PMID: 29237829
Recently, two influenza A virus (FLUAV) genomes were identified in Central and South American bats. These sequences exhibit notable divergence from classical FLUAV counterparts, and functionally, bat FLUAV glycoproteins lack...