Benjamin G Hale
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Explore the profile of Benjamin G Hale including associated specialties, affiliations and a list of published articles.
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56
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2406
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Recent Articles
11.
Busnadiego I, Abela I, Frey P, Hofmaenner D, Scheier T, Schuepbach R, et al.
PLoS Biol
. 2022 Jul;
20(7):e3001709.
PMID: 35788562
Autoantibodies neutralizing the antiviral action of type I interferons (IFNs) have been associated with predisposition to severe Coronavirus Disease 2019 (COVID-19). Here, we screened for such autoantibodies in 103 critically...
12.
Pohl M, Martin-Sancho L, Ratnayake R, White K, Riva L, Chen Q, et al.
ACS Infect Dis
. 2022 Jun;
8(7):1265-1279.
PMID: 35766385
There is a pressing need for host-directed therapeutics that elicit broad-spectrum antiviral activities to potentially address current and future viral pandemics. Apratoxin S4 (Apra S4) is a potent Sec61 inhibitor...
13.
Fernbach S, Spieler E, Busnadiego I, Karakus U, Lkharrazi A, Stertz S, et al.
Cell Rep
. 2022 Mar;
38(12):110549.
PMID: 35320721
Host interferons (IFNs) powerfully restrict viruses through the action of several hundred IFN-stimulated gene (ISG) products, many of which remain uncharacterized. Here, using RNAi screening, we identify several ISG restriction...
14.
Hale B
Curr Opin Virol
. 2021 Dec;
52:211-216.
PMID: 34959082
Host silencing of transposable elements (TEs) is critical to prevent genome damage and inappropriate inflammation. However, new evidence suggests that a virus-infected host may re-activate TEs and co-opt them for...
15.
Mazel-Sanchez B, Iwaszkiewicz J, Bonifacio J, Silva F, Niu C, Strohmeier S, et al.
Proc Natl Acad Sci U S A
. 2021 Sep;
118(36).
PMID: 34479996
Excessive production of viral glycoproteins during infections poses a tremendous stress potential on the endoplasmic reticulum (ER) protein folding machinery of the host cell. The host cell balances this by...
16.
Borold J, Eletto D, Busnadiego I, Mair N, Moritz E, Schiefer S, et al.
EMBO Rep
. 2021 Aug;
22(10):e52823.
PMID: 34397140
Interferon (IFN) induction of IFN-stimulated genes (ISGs) creates a formidable protective antiviral state. However, loss of appropriate control mechanisms can result in constitutive pathogenic ISG upregulation. Here, we used genome-scale...
17.
Pohl M, Busnadiego I, Marrafino F, Wiedmer L, Hunziker A, Fernbach S, et al.
J Gen Virol
. 2021 Jul;
102(7).
PMID: 34319869
Rapid repurposing of existing drugs as new therapeutics for COVID-19 has been an important strategy in the management of disease severity during the ongoing SARS-CoV-2 pandemic. Here, we used high-throughput...
18.
Echavarria-Consuegra L, Cook G, Busnadiego I, Lefevre C, Keep S, Brown K, et al.
PLoS Pathog
. 2021 Jun;
17(6):e1009644.
PMID: 34138976
Coronavirus infection induces the unfolded protein response (UPR), a cellular signalling pathway composed of three branches, triggered by unfolded proteins in the endoplasmic reticulum (ER) due to high ER load....
19.
Palika A, Armanious A, Rahimi A, Medaglia C, Gasbarri M, Handschin S, et al.
Nat Nanotechnol
. 2021 Jun;
16(8):918-925.
PMID: 34083772
Minimizing the spread of viruses in the environment is the first defence line when fighting outbreaks and pandemics, but the current COVID-19 pandemic demonstrates how difficult this is on a...
20.
Hale B
Elife
. 2021 May;
10.
PMID: 34003114
When culturing SARS-CoV-2 in the laboratory it is vital to avoid deletions in the gene for the spike protein that could affect the interpretation of experiments.