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Richard E Randall

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Articles 51
Citations 3834
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Recent Articles
1.
Vasou A, Nightingale K, Cetkovska V, Scheler J, Bamford C, Andrejeva J, et al.
Eur J Immunol . 2025 Feb; 55(2):e202451651. PMID: 39931755
Type I interferon (IFN) signalling induces the expression of several hundred IFN-stimulated genes (ISGs) that provide an unfavourable environment for viral replication. To prevent an overexuberant response and autoinflammatory disease,...
2.
Randall R, Young D, Pisliakova M, Andrejeva J, West L, Rossler L, et al.
J Gen Virol . 2025 Jan; 106(1. PMID: 39786361
Parainfluenza virus type 5 (PIV5) can cause either persistent or acute/lytic infections in a wide range of mammalian tissue culture cells. Here, we have generated PIV5 fusion (F)-expressing helper cell...
3.
Randall R, Young D, Hughes D, Goodbourn S
J Gen Virol . 2023 Nov; 104(11). PMID: 37962188
Parainfluenza virus type 5 (PIV5) can either have a persistent or a lytic phenotype in cultured cells. We have previously shown that the phenotype is determined by the phosphorylation status...
4.
Hardy A, Bakshi S, Furnon W, MacLean O, Gu Q, Varjak M, et al.
mBio . 2023 Apr; 14(3):e0010123. PMID: 37097030
Infected hosts possess two alternative strategies to protect themselves against the negative impact of virus infections: resistance, used to abrogate virus replication, and disease tolerance, used to avoid tissue damage...
5.
Lian C, Young D, Randall R, Samuel I
Biosensors (Basel) . 2022 Dec; 12(12). PMID: 36551092
Immunodiagnostics have been widely used in the detection of disease biomarkers. The conventional immunological tests in central laboratories require expensive equipment and, for non-specialists, the tests are technically demanding and...
6.
Daza-Cajigal V, Albuquerque A, Young D, Ciancanelli M, Moulding D, Angulo I, et al.
Front Immunol . 2022 Sep; 13:888427. PMID: 36159783
Purpose: Janus kinase-1 (JAK1) tyrosine kinase mediates signaling from multiple cytokine receptors, including interferon alpha/beta and gamma (IFN-α/β and IFN-γ), which are important for viral and mycobacterial protection respectively. We...
7.
Duncan C, Randall R, Hambleton S
Trends Genet . 2020 Sep; 37(1):46-58. PMID: 32977999
The concept that type I interferons (IFN-I) are essential to antiviral immunity derives from studies on animal models and cell lines. Virtually all pathogenic viruses have evolved countermeasures to IFN-I...
8.
Holthaus D, Vasou A, Bamford C, Andrejeva J, Paulus C, Randall R, et al.
J Immunol . 2020 May; 205(1):261-271. PMID: 32423918
IFNs, produced during viral infections, induce the expression of hundreds of IFN-stimulated genes (ISGs). Some ISGs have specific antiviral activity, whereas others regulate the cellular response. Besides functioning as an...
9.
Wignall-Fleming E, Vasou A, Young D, Short J, Hughes D, Goodbourn S, et al.
J Virol . 2020 Apr; 94(13). PMID: 32295916
During the replication of parainfluenza virus 5 (PIV5), copyback defective virus genomes (DVGs) are erroneously produced and are packaged into "infectious" virus particles. Copyback DVGs are the primary inducers of...
10.
Duncan C, Thompson B, Chen R, Rice G, Gothe F, Young D, et al.
Sci Immunol . 2019 Dec; 4(42). PMID: 31836668
Excessive type I interferon (IFNα/β) activity is implicated in a spectrum of human disease, yet its direct role remains to be conclusively proven. We investigated two siblings with severe early-onset...