Benjamin G Hale
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Explore the profile of Benjamin G Hale including associated specialties, affiliations and a list of published articles.
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56
Citations
2406
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Recent Articles
1.
Groen K, Kuratli R, Sar L, Vasou A, Huber M, Hughes D, et al.
Eur J Immunol
. 2024 Oct;
54(12):e2451325.
PMID: 39367550
Interferons (IFNs) are a critical component of innate immune defenses and limit viral disease severity. To advance studies on IFNs and their neutralization by pathogenic autoantibodies, we generated a Renilla...
2.
Fernbach S, Mair N, Abela I, Groen K, Kuratli R, Lork M, et al.
J Exp Med
. 2024 Jul;
221(9).
PMID: 39017930
Autoantibodies neutralizing type I interferons (IFN-Is) can underlie infection severity. Here, we trace the development of these autoantibodies at high-resolution using longitudinal samples from 1,876 well-treated individuals living with HIV...
3.
Schiefer S, Hale B
Nat Commun
. 2024 May;
15(1):4484.
PMID: 38802340
Deciphering the intricate dynamic events governing type I interferon (IFN) signaling is critical to unravel key regulatory mechanisms in host antiviral defense. Here, we leverage TurboID-based proximity labeling coupled with...
4.
Achleitner M, Mair N, Danhardt J, Kardashi R, Puhan M, Abela I, et al.
Open Forum Infect Dis
. 2024 Jan;
11(1):ofad641.
PMID: 38179103
Genetic defects in the interferon (IFN) system or neutralizing autoantibodies against type I IFNs contribute to severe COVID-19. Such autoantibodies were proposed to affect post-COVID-19 syndrome (PCS), possibly causing persistent...
5.
Meissner R, Wixler V, Wulfert F, Jacob J, Hale B, Robeck T, et al.
Mol Ther Oncolytics
. 2023 Nov;
31:100741.
PMID: 38020062
Low pathogenic influenza A viruses (IAVs) have shown promising oncolytic potential in lung cancer-bearing mice. However, as replication-competent pathogens, they may cause side effects in immunocompromised cancer patients. To circumvent...
6.
Perakakis N, Harb H, Hale B, Varga Z, Steenblock C, Kanczkowski W, et al.
Lancet Diabetes Endocrinol
. 2023 Jul;
11(9):675-693.
PMID: 37524103
Viruses have been present during all evolutionary steps on earth and have had a major effect on human history. Viral infections are still among the leading causes of death. Another...
7.
Belavgeni A, Maremonti F, Tonnus W, Stadtmuller M, Gavali S, Mallais M, et al.
Proc Natl Acad Sci U S A
. 2023 May;
120(21):e2300320120.
PMID: 37186845
Iridoviridae, such as the lymphocystis disease virus-1 (LCDV-1) and other viruses, encode viral insulin-like peptides (VILPs) which are capable of triggering insulin receptors (IRs) and insulin-like growth factor receptors. The...
8.
Hale B
Eur J Immunol
. 2023 Apr;
53(6):e2250164.
PMID: 37027328
The type I IFN (IFN-I) system is essential to limit severe viral disease in humans. Thus, IFN-I deficiencies are associated with serious life-threatening infections. Remarkably, some rare individuals with chronic...
9.
Fernbach S, Hale B
PLoS Biol
. 2022 Sep;
20(9):e3001787.
PMID: 36103486
Writing in PLOS Biology, Ching and colleagues show that ACE2-decorated exosomes are deployed as natural inhibitory decoys against SARS-CoV-2. High decoy levels correlate with improved patient outcomes, suggesting they directly...
10.
Mair N, Hale B
Sci Rep
. 2022 Sep;
12(1):15360.
PMID: 36100643
The human type I interferon (IFN) system is central to innate immune defense, and is essential to protect individuals against severe viral disease. Consequently, genetic disruption of IFN signaling or...