Matthew P Jacobson
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Explore the profile of Matthew P Jacobson including associated specialties, affiliations and a list of published articles.
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175
Citations
8464
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Recent Articles
1.
Kumbier K, Roth M, Li Z, Lazzari-Dean J, Waters C, Hammerlindl S, et al.
Dev Cell
. 2024 Jun;
59(16):2134-2142.e6.
PMID: 38878774
Amyotrophic lateral sclerosis (ALS) is a rapidly progressing, highly heterogeneous neurodegenerative disease, underscoring the importance of obtaining information to personalize clinical decisions quickly after diagnosis. Here, we investigated whether ALS-relevant...
2.
Kisor K, Ruiz D, Jacobson M, Barber D
bioRxiv
. 2024 Jun;
PMID: 38826444
Intracellular pH (pHi) dynamics regulates diverse cell processes such as proliferation, dysplasia, and differentiation, often mediated by the protonation state of a functionally critical histidine residue in endogenous pH sensing...
3.
Leyte-Vidal A, Ruiz D, DeFilippis R, Leske I, Rea D, Phan S, et al.
Blood
. 2024 Apr;
144(6):639-645.
PMID: 38643492
Secondary kinase domain mutations in BCR::ABL1 represent the most common cause of resistance to tyrosine kinase inhibitor (TKI) therapy in patients with chronic myeloid leukemia. The first 5 approved BCR::ABL1...
4.
Paolino J, Dimitrov B, Winger B, Sandoval-Perez A, Rangarajan A, Ocasio-Martinez N, et al.
Clin Cancer Res
. 2023 Sep;
29(22):4613-4626.
PMID: 37725576
Purpose: Patients with relapsed or refractory T-cell acute lymphoblastic leukemia (T-ALL) or lymphoblastic lymphoma (T-LBL) have limited therapeutic options. Clinical use of genomic profiling provides an opportunity to identify targetable...
5.
Li L, Shen S, Bickler P, Jacobson M, Wu L, Altschuler S
Elife
. 2023 Jul;
12.
PMID: 37494095
The ability to sense and respond to changes in cellular oxygen levels is critical for aerobic organisms and requires a molecular oxygen sensor. The prototypical sensor is the oxygen-dependent enzyme...
6.
Sampognaro P, Arya S, Knudsen G, Gunderson E, Sandoval-Perez A, Hodul M, et al.
Mol Neurodegener
. 2023 May;
18(1):34.
PMID: 37254128
No abstract available.
7.
Rehan S, Tranter D, Sharp P, Craven G, Lowe E, Anderl J, et al.
Nat Chem Biol
. 2023 May;
19(9):1054-1062.
PMID: 37169961
Preventing the biogenesis of disease-relevant proteins is an attractive therapeutic strategy, but attempts to target essential protein biogenesis factors have been hampered by excessive toxicity. Here we describe KZR-8445, a...
8.
Rinaldi C, Waters C, Li Z, Kumbier K, Rao L, Nichols R, et al.
Cell Rep
. 2023 May;
42(5):112447.
PMID: 37141099
Parkinson's disease-causing leucine-rich repeat kinase 2 (LRRK2) mutations lead to varying degrees of Rab GTPase hyperphosphorylation. Puzzlingly, LRRK2 GTPase-inactivating mutations-which do not affect intrinsic kinase activity-lead to higher levels of...
9.
Sampognaro P, Arya S, Knudsen G, Gunderson E, Sandoval-Perez A, Hodul M, et al.
Mol Neurodegener
. 2023 May;
18(1):29.
PMID: 37131250
Background: Autosomal dominant mutations in α-synuclein, TDP-43 and tau are thought to predispose to neurodegeneration by enhancing protein aggregation. While a subset of α-synuclein, TDP-43 and tau mutations has been...
10.
Sandoval-Perez A, Winger B, Jacobson M
J Chem Theory Comput
. 2022 Dec;
19(1):376.
PMID: 36493348
No abstract available.