Benjamin Cravatt
Overview
Explore the profile of Benjamin Cravatt including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
21
Citations
850
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Akefe I, Saber S, Matthews B, Venkatesh B, Gormal R, Blackmore D, et al.
EMBO J
. 2024 Feb;
43(4):533-567.
PMID: 38316990
The phospholipid and free fatty acid (FFA) composition of neuronal membranes plays a crucial role in learning and memory, but the mechanisms through which neuronal activity affects the brain's lipid...
2.
Zhang Y, Liu Z, Hirschi M, Brodsky O, Johnson E, Won S, et al.
bioRxiv
. 2024 Jan;
PMID: 38293178
More than half of the ~20,000 protein-encoding human genes have at least one paralog. Chemical proteomics has uncovered many electrophile-sensitive cysteines that are exclusive to a subset of paralogous proteins....
3.
Bainbridge M, Mazumder A, Ogasawara D, Abou Jamra R, Bernard G, Bertini E, et al.
Brain
. 2022 Jun;
145(10):3383-3390.
PMID: 35737950
The endocannabinoid system is a highly conserved and ubiquitous signalling pathway with broad-ranging effects. Despite critical pathway functions, gene variants have not previously been conclusively linked to human disease. We...
4.
Cheng R, Fujinaga M, Yang J, Rong J, Haider A, Ogasawara D, et al.
Acta Pharmacol Sin
. 2022 May;
43(11):3002-3010.
PMID: 35513432
Monoacylglycerol lipase (MAGL) constitutes a serine hydrolase that orchestrates endocannabinoid homeostasis and exerts its function by catalyzing the degradation of 2-arachidonoylglycerol (2-AG) to arachidonic acid (AA). As such, selective inhibition...
5.
Bouffard E, Zaro B, Dix M, Cravatt B, Wong C
Tetrahedron Lett
. 2021 Nov;
74.
PMID: 34764521
Non-small-cell lung cancer (NSCLC) is a major disease that accounts for 85% of all lung cancer cases which claimed around 1.8 billion lives worldwide in 2020. Tyrosine kinase inhibitors (TKIs)...
6.
Chefetz I, Grimley E, Yang K, Hong L, Vinogradova E, Suciu R, et al.
Cell Rep
. 2019 Mar;
26(11):3061-3075.e6.
PMID: 30865894
Ovarian cancer is typified by the development of chemotherapy resistance. Chemotherapy resistance is associated with high aldehyde dehydrogenase (ALDH) enzymatic activity, increased cancer "stemness," and expression of the stem cell...
7.
Baillargeon P, Fernandez-Vega V, Sridharan B, Brown S, Griffin P, Rosen H, et al.
SLAS Discov
. 2019 Jan;
24(3):386-397.
PMID: 30682260
The Scripps Research Molecular Screening Center (SRMSC) was founded in 2004 and comprises more than $22 million of specialized automation. As part of the Translational Research Institute (TRI), it comprises...
8.
Gavin A, Huang D, Huber C, Martensson A, Tardif V, Skog P, et al.
Nat Immunol
. 2018 Aug;
19(9):942-953.
PMID: 30111894
The sensing of microbial genetic material by leukocytes often elicits beneficial pro-inflammatory cytokines, but dysregulated responses can cause severe pathogenesis. Genome-wide association studies have linked the gene encoding phospholipase D3...
9.
Manterola A, Bernal-Chico A, Cipriani R, Canedo-Antelo M, Moreno-Garcia A, Martin-Fontecha M, et al.
Biochem Pharmacol
. 2018 Aug;
157:189-201.
PMID: 30075103
Multiple sclerosis (MS) is a chronic demyelinating disease of unknown etiology in which tissue pathology suggests both immune-dependent attacks to oligodendroglia and primary oligodendrocyte demise. The endocannabinoid system has been...
10.
Sousa-Valente J, Varga A, Torres-Perez J, Jenes A, Wahba J, Mackie K, et al.
J Comp Neurol
. 2016 Dec;
525(8):1778-1796.
PMID: 27997038
Elevation of intracellular Ca concentration induces the synthesis of N-arachydonoylethanolamine (anandamide) in a subpopulation of primary sensory neurons. N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) is the only known enzyme that synthesizes anandamide...