Beate Eckes
Overview
Explore the profile of Beate Eckes including associated specialties, affiliations and a list of published articles.
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Articles
75
Citations
1900
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Recent Articles
1.
Zeinert I, Schmidt L, Baar T, Gatto G, De Giuseppe A, Korb-Pap A, et al.
Exp Cell Res
. 2025 Jan;
445(1):114408.
PMID: 39765309
Fibroblast-like synoviocytes (FLS) are key cells promoting cartilage damage and bone loss in rheumatoid arthritis (RA). They are activated to assume an invasive and migratory phenotype. While mechanisms of FLS...
2.
Schiavinato A, Marcous F, Zuk A, Keene D, Tufa S, Mosquera L, et al.
Sci Rep
. 2024 Dec;
14(1):30345.
PMID: 39639116
Supramolecular extracellular matrix (ECM) networks play an essential role in skin architecture and function. Elastin microfibril interface-located proteins (EMILINs) comprise a family of three extracellular glycoproteins that serve as essential...
3.
Trinh-Minh T, Chen C, Tran Manh C, Li Y, Zhu H, Zhou X, et al.
J Clin Invest
. 2024 May;
134(10).
PMID: 38747285
Transforming growth factor β (TGF-β) signaling is a core pathway of fibrosis, but the molecular regulation of the activation of latent TGF-β remains incompletely understood. Here, we demonstrate a crucial...
4.
Raote I, Rosendahl A, Hakkinen H, Vibe C, Kucukaylak I, Sawant M, et al.
Nat Commun
. 2024 Apr;
15(1):3302.
PMID: 38658535
Uncontrolled secretion of ECM proteins, such as collagen, can lead to excessive scarring and fibrosis and compromise tissue function. Despite the widespread occurrence of fibrotic diseases and scarring, effective therapies...
5.
Sawant M, Wang F, Koester J, Niehoff A, Nava M, Lundgren-Akerlund E, et al.
Ann Rheum Dis
. 2023 Jul;
82(11):1474-1486.
PMID: 37479494
Objectives: Activation of fibroblasts is a hallmark of fibrotic processes. Besides cytokines and growth factors, fibroblasts are regulated by the extracellular matrix environment through receptors such as integrins, which transduce...
6.
Zehender A, Li Y, Lin N, Stefanica A, Nuchel J, Chen C, et al.
Nat Commun
. 2021 Jul;
12(1):4404.
PMID: 34285225
Activation of fibroblasts is essential for physiological tissue repair. Uncontrolled activation of fibroblasts, however, may lead to tissue fibrosis with organ dysfunction. Although several pathways capable of promoting fibroblast activation...
7.
Nuchel J, Tauber M, Nolte J, Morgelin M, Turk C, Eckes B, et al.
Mol Cell
. 2021 Jul;
81(16):3275-3293.e12.
PMID: 34245671
Cells communicate with their environment via surface proteins and secreted factors. Unconventional protein secretion (UPS) is an evolutionarily conserved process, via which distinct cargo proteins are secreted upon stress. Most...
8.
Sawant M, Hinz B, Schonborn K, Zeinert I, Eckes B, Krieg T, et al.
Wound Repair Regen
. 2021 Jun;
29(4):515-530.
PMID: 34081361
Our skin is continuously exposed to mechanical challenge, including shear, stretch, and compression. The extracellular matrix of the dermis is perfectly suited to resist these challenges and maintain integrity of...
9.
Alam J, Musiime M, Romaine A, Sawant M, Melleby A, Lu N, et al.
Matrix Biol Plus
. 2021 Feb;
8:100045.
PMID: 33543038
Cell-specific expression of genes offers the possibility to use their promoters to drive expression of Cre-recombinase, thereby allowing for detailed expression analysis using reporter gene systems, cell lineage tracing, conditional...
10.
Auler M, Bergmeier V, Georgieva V, Pitzler L, Frie C, Nuchel J, et al.
J Invest Dermatol
. 2020 Dec;
141(4S):1076-1086.e3.
PMID: 33279585
During wound healing, fibroblasts differentiate into nonproliferative contractile myofibroblasts, contribute to skin repair, and eventually undergo apoptosis or become senescent. MicroRNAs are post-transcriptional regulators of gene expression networks that control...