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Bartolome Vilanova

Explore the profile of Bartolome Vilanova including associated specialties, affiliations and a list of published articles. Areas
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Articles 28
Citations 179
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Recent Articles
11.
Ramis R, Ortega-Castro J, Casasnovas R, Marino L, Vilanova B, Adrover M, et al.
J Chem Inf Model . 2019 Apr; 59(4):1458-1471. PMID: 30933517
Intrinsically disordered proteins (IDPs) are not well described by a single 3D conformation but by an ensemble of them, which makes their structural characterization especially challenging, both experimentally and computationally....
12.
Marino L, Casasnovas R, Ramis R, Vilanova B, Ortega-Castro J, Frau J, et al.
Int J Biol Macromol . 2019 Feb; 129:254-266. PMID: 30738904
The understanding of the effect of non-enzymatic post-translational modifications on the protein structure is essential to unveil the molecular mechanisms underlying their related pathological processes. Among those modifications, protein glycation...
13.
Ramis R, Ortega-Castro J, Vilanova B, Adrover M, Frau J
J Phys Chem A . 2017 Dec; 122(2):690-699. PMID: 29243928
The interactions between the protein α-synuclein and the Zn(II) and Al(III) cations at different sites were studied at the M06/6-311+G(d,p)/SMD and the ωB97X-D/6-311+G(d,p)/SMD levels of theory. For Zn(II), previous experimental...
14.
Ramis R, Ortega-Castro J, Vilanova B, Adrover M, Frau J
J Phys Chem A . 2017 Jul; 121(30):5711-5719. PMID: 28691818
The interactions between N-terminally acetylated α-synuclein and Cu(II) at several binding sites have been studied with DFT calculations, specifically with the M06 hybrid functional and the ωB97X-D DFT-D functional. In...
15.
Marino L, Maya-Aguirre C, Pauwels K, Vilanova B, Ortega-Castro J, Frau J, et al.
ACS Chem Biol . 2017 Mar; 12(4):1152-1162. PMID: 28257177
Glycation occurs in vivo as a result of the nonenzymatic reaction of carbohydrates (and/or their autoxidation products) with proteins, DNA, or lipids. Protein glycation causes loss-of-function and, consequently, the development...
16.
Marino L, Pauwels K, Casasnovas R, Sanchis P, Vilanova B, Munoz F, et al.
Sci Rep . 2015 Jul; 5:12052. PMID: 26169912
Protein aggregation with the concomitant formation of amyloid fibrils is related to several neurodegenerative diseases, but also to non-neuropathic amyloidogenic diseases and non-neurophatic systemic amyloidosis. Lysozyme is the protein involved...
17.
Vilanova B, Sanfelice D, Martorell G, Temussi P, Pastore A
Front Mol Biosci . 2015 May; 1:13. PMID: 25988154
Yfh1, the yeast ortholog of frataxin, is a protein of limited thermodynamic stability which undergoes cold denaturation at temperatures above the water freezing point. We have previously demonstrated that its...
18.
Adrover M, Marino L, Sanchis P, Pauwels K, Kraan Y, Lebrun P, et al.
Biomacromolecules . 2014 Jul; 15(9):3449-62. PMID: 25057908
Protein glycation causes loss-of-function through a process that has been associated with several diabetic-related diseases. Additionally, glycation has been hypothesized as a promoter of protein aggregation, which could explain the...
19.
Caldes C, Vilanova B, Adrover M, Donoso J, Munoz F
Bioorg Med Chem Lett . 2013 Mar; 23(7):2202-6. PMID: 23462644
Schiff bases (SBs) are the initial products of non-enzymatic glycation reactions, which are associated to some diabetes-related diseases. In this work, we used physiological pH and temperature conditions to study...
20.
Vilanova B, Gallardo J, Caldes C, Adrover M, Ortega-Castro J, Munoz F, et al.
J Phys Chem A . 2012 Jan; 116(8):1897-905. PMID: 22280506
Pyridoxal 5'-phosphate (PLP) is a B(6) vitamer acting as an enzyme cofactor in various reactions of aminoacid metabolism and inhibiting glycation of biomolecules. Nonenzymatic glycation of aminophospholipids alters the stability...