Bart L Staker
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Explore the profile of Bart L Staker including associated specialties, affiliations and a list of published articles.
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81
Citations
1777
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Recent Articles
1.
Grote D, Stewart C, Daraji D, Enayati P, Braverman K, Romanaggi C, et al.
Acta Crystallogr F Struct Biol Commun
. 2025 Mar;
PMID: 40035494
The methylerythritol phosphate (MEP) pathway is a metabolic pathway that produces the isoprenoids isopentyl pyrophosphate and dimethylallyl pyrophosphate. Notably, the MEP pathway is present in bacteria and not in mammals,...
2.
Baral J, Song D, Edwards T, Dranow D, Lorimer D, Staker B, et al.
Acta Crystallogr F Struct Biol Commun
. 2025 Mar;
PMID: 40023769
Neisseria gonorrhoeae, the causative agent of the human disease gonorrhea, is the second most common sexually transmitted pathogen in the United States. Gonorrhea has a significantly high morbidity rate due...
3.
Jezewski A, Krysan D, Alden K, Daraji D, Lail 3rd C, Propp J, et al.
Res Sq
. 2025 Jan;
PMID: 39801522
Acetyl CoA synthetases (ACS) have emerged as drug targets for the treatment of cancer, metabolic diseases as well as fungal and parasitic infections. Although a variety of small molecule ACS...
4.
Sigalapalli D, Groustra S, Fenwick M, Zigweid R, Hulverson M, Owsley E, et al.
Bioorg Med Chem Lett
. 2025 Jan;
119:130092.
PMID: 39778753
Cryptosporidium parvum is a protozoan parasite that causes severe diarrheal illness in children and each year nearly 50,000 children under age 5 die due to the disease. Despite tremendous research...
5.
Fenwick M, Pierce P, Abendroth J, Barrett K, Barrett L, Bowatte K, et al.
Commun Biol
. 2024 Dec;
7(1):1622.
PMID: 39639052
Griselimycin, a cyclic depsidecapeptide produced by Streptomyces griseus, is a promising lead inhibitor of the sliding clamp component of bacterial DNA polymerases (β-subunit of Escherichia coli DNA pol III). It...
6.
Andrade Meirelles M, Almeida V, Sullivan J, de Toledo I, Dos Reis C, Cunha M, et al.
J Med Chem
. 2024 Oct;
67(21):19143-19164.
PMID: 39468773
Nontuberculous mycobacteria (NTM) are emerging human pathogens linked to severe pulmonary diseases. Current treatments involve the prolonged use of multiple drugs and are often ineffective. Bacterial dihydrofolate reductase (DHFR) is...
7.
Jezewski A, Esan T, Propp J, Fuller A, Daraji D, Lail 3rd C, et al.
J Biol Chem
. 2024 Oct;
300(11):107879.
PMID: 39395803
Leishmania, a protozoan parasite, is responsible for significant morbidity and mortality worldwide, manifesting as cutaneous, mucocutaneous, and visceral leishmaniasis. These diseases pose a substantial burden, especially in impoverished regions with...
8.
Gilleran J, Ashraf K, Delvillar M, Eck T, Fondekar R, Miller E, et al.
J Med Chem
. 2024 Jul;
67(14):12459.
PMID: 38984428
No abstract available.
9.
Rodriguez-Hernandez D, Fenwick M, Zigweid R, Sankaran B, Myler P, Sunnerhagen P, et al.
J Med Chem
. 2024 Apr;
67(9):7312-7329.
PMID: 38680035
-myristoyltransferase (NMT) is a promising antimalarial drug target. Despite biochemical similarities between and human NMTs, our recent research demonstrated that high selectivity is achievable. Herein, we report NMT-inhibiting compounds aimed...
10.
Ran X, Parikh P, Abendroth J, Arakaki T, Clifton M, Edwards T, et al.
Acta Crystallogr F Struct Biol Commun
. 2024 Apr;
80(Pt 4):82-91.
PMID: 38656226
The rise in antimicrobial resistance is a global health crisis and necessitates the development of novel strategies to treat infections. For example, in 2022 tuberculosis (TB) was the second leading...