Jan Abendroth
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Explore the profile of Jan Abendroth including associated specialties, affiliations and a list of published articles.
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95
Citations
1317
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Recent Articles
1.
Teng S, Wang J, Sroge C, Abendroth J, Lorimer D, Horanyi P, et al.
Acta Crystallogr F Struct Biol Commun
. 2025 Mar;
PMID: 40059638
Mycobacterium tuberculosis is a Gram-positive bacillus that causes tuberculosis and is a leading cause of mortality worldwide. This disease is a growing health threat due to the occurrence of multidrug...
2.
Grote D, Stewart C, Daraji D, Enayati P, Braverman K, Romanaggi C, et al.
Acta Crystallogr F Struct Biol Commun
. 2025 Mar;
PMID: 40035494
The methylerythritol phosphate (MEP) pathway is a metabolic pathway that produces the isoprenoids isopentyl pyrophosphate and dimethylallyl pyrophosphate. Notably, the MEP pathway is present in bacteria and not in mammals,...
3.
Sharma N, Turlington Z, Zupko S, Catoggio M, Lukacs C, Serbzhinskiy D, et al.
Arch Biochem Biophys
. 2025 Feb;
766:110332.
PMID: 39938730
Orotate phosphoribosyltransferase (OPRT) catalyzes the reaction that adds the pyrimidine base to the ribose in the penultimate step of the de novo biosynthesis of pyrimidine nucleotides. The OPRT structure consists...
4.
Mendez A, Bolling C, Taylor S, Makumire S, Staker B, Reers A, et al.
Acta Crystallogr F Struct Biol Commun
. 2024 Dec;
81(Pt 1):1-10.
PMID: 39655507
Plasmodium vivax, a significant contributor to global malaria cases, poses an escalating health burden on a substantial portion of the world's population. The increasing spread of P. vivax because of...
5.
Fenwick M, Pierce P, Abendroth J, Barrett K, Barrett L, Bowatte K, et al.
Commun Biol
. 2024 Dec;
7(1):1622.
PMID: 39639052
Griselimycin, a cyclic depsidecapeptide produced by Streptomyces griseus, is a promising lead inhibitor of the sliding clamp component of bacterial DNA polymerases (β-subunit of Escherichia coli DNA pol III). It...
6.
Poullennec K, Jnoff E, Abendroth J, Bhuma N, Calmiano M, Calmus L, et al.
J Med Chem
. 2024 Nov;
67(23):20879-20910.
PMID: 39588908
Nuak1 (NUAK family SnF1-like kinase-1) is a serine-threonine kinase and a member of the AMPK family. Interest in Nuak1 has increased over the years due to the role it plays...
7.
Chakafana G, Boswell R, Chandler A, Jackson K, Neblett S, Postal T, et al.
Acta Crystallogr F Struct Biol Commun
. 2024 Aug;
80(Pt 9):193-199.
PMID: 39177244
Brucella ovis is an etiologic agent of ovine epididymitis and brucellosis that causes global devastation in sheep, rams, goats, small ruminants and deer. There are no cost-effective methods for the...
8.
Nagashima K, Dzimianski J, Yang M, Abendroth J, Sautto G, Ross T, et al.
Structure
. 2024 May;
32(8):1079-1089.e6.
PMID: 38810648
Influenza causes significant morbidity and mortality. As an alternative approach to current seasonal vaccines, the computationally optimized broadly reactive antigen (COBRA) platform has been previously applied to hemagglutinin (HA). This...
9.
Ran X, Parikh P, Abendroth J, Arakaki T, Clifton M, Edwards T, et al.
Acta Crystallogr F Struct Biol Commun
. 2024 Apr;
80(Pt 4):82-91.
PMID: 38656226
The rise in antimicrobial resistance is a global health crisis and necessitates the development of novel strategies to treat infections. For example, in 2022 tuberculosis (TB) was the second leading...
10.
De Vitto H, Belfon K, Sharma N, Toay S, Abendroth J, Dranow D, et al.
Biochemistry
. 2024 Feb;
PMID: 38306231
Thiamin and its phosphate derivatives are ubiquitous molecules involved as essential cofactors in many cellular processes. The biosynthesis of thiamin employs the parallel synthesis of 4-methyl-5-(2-hydroxyethyl)thiazole (THZ-P) and 4-amino-2-methyl-5(diphosphooxymethyl) pyrimidine...